2gwj: Difference between revisions
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==SpvB ADP-ribosylated actin: hexagonal crystal form== | ==SpvB ADP-ribosylated actin: hexagonal crystal form== | ||
<StructureSection load='2gwj' size='340' side='right' caption='[[2gwj]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2gwj' size='340' side='right'caption='[[2gwj]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gwj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gwj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWJ FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2gwj" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2gwj" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Actin 3D structures|Actin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: European rabbit]] | [[Category: European rabbit]] | ||
[[Category: Large Structures]] | |||
[[Category: Margarit, S M]] | [[Category: Margarit, S M]] | ||
[[Category: Stebbins, C E]] | [[Category: Stebbins, C E]] | ||
Revision as of 12:18, 24 July 2019
SpvB ADP-ribosylated actin: hexagonal crystal formSpvB ADP-ribosylated actin: hexagonal crystal form
Structural highlights
Function[ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Publication Abstract from PubMedSalmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal structure of the catalytic domain of SpvB, and we show by mass spectrometric analysis that SpvB modifies actin at Arg177, inhibiting its ATPase activity. We also describe two crystal structures of SpvB-modified, polymerization-deficient actin. These structures reveal that ADP-ribosylation does not lead to dramatic conformational changes in actin, suggesting a model in which this large family of toxins inhibits actin polymerization primarily through steric disruption of intrafilament contacts. A steric antagonism of actin polymerization by a salmonella virulence protein.,Margarit SM, Davidson W, Frego L, Stebbins CE Structure. 2006 Aug;14(8):1219-29. PMID:16905096[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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