Fatty acid-binding protein: Difference between revisions

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</StructureSection>
</StructureSection>


==3D structures of fatty acid-binding protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Intestinal fatty acid-binding protein
**[[1kzw]], [[3ifb]] - hIFABP – human – NMR<BR />
**[[1kzx]] - hIFABP (mutant) – NMR<BR />
**[[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR />
**[[1t8v]] - rIFABP (mutant) – NMR<BR />
**[[1ifb]], [[1ifc]] - rIFABP <br />
**[[1dc9]] - rIFABP (mutant)<br />
*''Intestinal fatty acid-binding protein binary complex''
**[[3akm]], [[2mo5]] - hIFABP + fatty acid analog<br />
**[[2mji]] - hIFABP + ketorolac - NMR<br />
**[[3akn]], [[1icm]], [[1icn]], [[2ifb]] - rIFABP + fatty acid analog<br />
**[[1ure]] - rIFABP + palmitate – NMR<BR />
*Epidermal fatty acid-binding protein
**[[1b56]], [[1jjj]], [[4lkp]] - hEFABP <br />
**[[4azr]], [[4lkt]] - hEFABP + fatty acid<br />
**[[4azm]], [[5ur9]], [[5hz5]] - hEFABP + inhibitor<br />
**[[4azn]], [[4azo]] - mEFABP <br />
**[[4azp]], [[4azq]] - mEFABP + fatty acid<br />
*Heart-type fatty acid-binding protein
**[[1g5w]] - hHFABP – NMR<BR />
**[[3rsw]], [[5ce4]], [[6aq1]] – hHFABP<br />
**[[3wbg]] – hHFABP + sulfonate derivative<br />
**[[5hz9]] – hHFABP + inhibitor<br />
**[[3wvm]], [[4tjz]], [[4tkb]], [[4tkh]], [[4tkj]], [[4wbk]], [[3wxq]] - hHFABP + fatty acid<br />
**[[5b29]], [[5b28]], [[5b27]] - hHFABP (mutant) + fatty acid<br />
**[[1bwy]] – HFABP – bovine<br />
**[[5d8j]] – HFABP + Fab – mouse<br />
*Brain-type fatty acid-binding protein
**[[1fdq]], [[1jjx]] - hBFABP<br />
**[[1fe3]] - hBFABP + oleate<br />
**[[5ura]] - hBFABP + inhibitor <br />
*Liver-type fatty acid-binding protein
**[[2f73]], [[3stn]], [[3b2h]], [[3b2i]], [[3b2j]], [[3b2k]], [[3b2l]], [[3vg2]], [[3vg3]], [[3vg4]], [[3vg5]], [[3vg6]], [[3vg7]] - hLFABP<br />
**[[2py1]], [[2l67]], [[2l68]] - hLFABP – NMR<BR />
**[[1tvq]], [[1mvg]] - cLFABP – chicken<br />
**[[1zry]] - cLFABP - NMR<BR />
**[[2ju3]], [[2ju7]] - rLFABP – NMR<BR />
**[[1p6p]] - LFABP – toad<br />
**[[2ft9]] – AmLFABP - ''Ambystoma mexicanum''
*''Liver-type fatty acid-binding protein binary complex''
**[[3stk]], [[3stm]] - hLFABP + palmitate<br />
**[[2lkk]] - hLFABP + oleate – NMR<br />
**[[2ju8]] - rLFABP + oleate – NMR<BR />
**[[1lfo]] - rLFABP + oleate<br />
**[[1tw4]], [[2jn3]], [[2lfo]] - cLFABP + cholate<br />
**[[2jn3]] - cLFABP + chenodeoxycholate<br />
**[[2k62]] - cLFABP + bile acid-based Gd chelate<br />
**[[2ftb]] - AmLFABP + oleate<br />
**[[2qo4]] – zLFABP + cholate – zebrafish<br />
**[[2qo5]], [[2qo6]] – zLFABP (mutant) + cholate <br />
*Adipocyte fatty acid-binding protein
**[[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br />
**[[1tow]] - hAFABP + carbazole butanoic acid<br />
**[[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]], [[5hz6]], [[5hz8]], [[5d45]], [[5d47]], [[5d48]], [[5d4a]], [[5edb]], [[5edc]], [[4nns]], [[4nnt]], [[5y0f]], [[5y0g]], [[5y0x]], [[5y12]], [[5y13]] - hAFABP + inhibitor<br />
**[[3p6c]] - hAFABP + citrate<br />
**[[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br />
**[[3p6f]] - hAFABP + phenyl-butyrate<br />
**[[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br />
**[[6ayl]] - hAFABP + fluorescein <br />
**[[1lib]], [[1alb]] – mAFABP<br />
**[[1g7n]], [[1ab0]], [[1acd]] - mAFABP (mutant) <br />**[[2qm9]] - mAFABP + troglitazone <br />
**[[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br />
**[[1g74]] - mAFABP (mutant) + fatty acid <br />
**[[3hk1]], [[3js1]], [[3jsq]] - mAFABP + inhibitor<br />
**[[1lic]], [[2ans]] – mAFABP + sulfonic acid derivative<br />
**[[1a18]] - mAFABP + phenanthroline <br />
**[[1a2d]] - mAFABP + pyridoxamine <br />
**[[5c0n]] - mAFABP + Fab <br />
*Flight muscle fatty acid-binding protein
**[[2flj]], [[1ftp]] - LMFABP – locust
*Muscle fatty acid-binding protein
**[[2hmb]] – hMFABP <br />
**[[1hmr]], [[1hms]], [[1hmt]] – hMFABP + fatty acid<br />
*Testis fatty acid-binding protein
**[[4a60]] - hTFABP
*Ileal bile acid-binding protein (Gastrotropin)
**[[1o1u]], [[5l8i]] – hIBABP <br />
**[[1o1v]] – hIBABP + cholytaurine<br />
**[[2mm3]], [[5l8o]] – hIBABP + cholate<br />
**[[5l8n]] – hIBABP + inhibitor<br />
**[[1eal]] – pIBABP - pig <br />
**[[1eio]] – pIBABP + cholate<br />
**[[3elx]] – zIBABP <br />
**[[3elz]], [[3em0]] – zIBABP + cholate<br />
*Other fatty acid-binding protein
**[[2poa]] - SmFABP (mutant) - ''Schistosoma mansoni'' – NMR<BR />
**[[1mdc]] – FABP – tobacco hornworm<br />
**[[4jgx]] - FABP – ''Yarrowia lipolytica''<br />
**[[1vyf]], [[1vyg]] – SmFABP + fatty acid<br />
**[[3w9k]] – FABP + fatty acid – ''Sulfolobus tokodaii''<br />
**[[2n93]] – FABP – ''Luciola cerata'' - NMR<br />
**[[5bvq]] – PpFABP – ''Pygoscelis papua'' <br />
**[[5bvs]], [[5bvt]] – PpFABP + fatty acid <br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:06, 26 June 2019


Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells[1]. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis.

Relevance

Some FABSs are linked to metabolic and inflammatory pathways.

Structural insights

The (Hydrophobic, Polar)[2].

3D structures of fatty acid-binding protein

Fatty acid-binding protein 3D structures


Human brain-type fatty acid-binding protein complex with oleate (PDB code 1fe3)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
  2. ↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200

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Michal Harel, Alexander Berchansky
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