Dethiobiotin synthetase: Difference between revisions
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<StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'> | <StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'> | ||
'''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref> | '''Dethiobiotin synthetase''' (DTBS) or '''ATP-depenent dethiobiotin synthetase''' catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref> | ||
== Structural highlights == | == Structural highlights == | ||
The <scene name='49/493028/Cv/5'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref> | The <scene name='49/493028/Cv/5'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref> | ||
==3D dethiobiotin synthetase== | |||
[[Dethiobiotin synthetase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==3D dethiobiotin synthetase== | ==3D dethiobiotin synthetase== | ||
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**[[3fmf]] – MtDTBS + DAN<br /> | **[[3fmf]] – MtDTBS + DAN<br /> | ||
**[[4wop]], [[6e05]], [[6e06]] - MtDTBS + CTP<br /> | |||
**[[6cvv]] - MtDTBS + ATP<br /> | |||
**[[6czd]] - MtDTBS + ADP<br /> | |||
**[[6vzb]] - MtDTBS + UTP<br /> | |||
**[[6czc]] - MtDTBS + TTP<br /> | |||
**[[6cze]] - MtDTBS + ITP<br /> | |||
**[[6cvu]] - MtDTBS + cytidine<br /> | |||
**[[4wop]] - MtDTBS + CTP<br /> | **[[4wop]] - MtDTBS + CTP<br /> | ||
**[[3fmi]] – MtDTBS + aminopelargonic acid<br /> | **[[3fmi]] – MtDTBS + aminopelargonic acid<br /> | ||
| Line 34: | Line 45: | ||
**[[1dag]] - EcDTBS + DAN + ATP derivative<br /> | **[[1dag]] - EcDTBS + DAN + ATP derivative<br /> | ||
**[[3qxj]] - HpDTBS + Mg + ATP<BR /> | **[[3qxj]] - HpDTBS + Mg + ATP<BR /> | ||
**[[3qxs]] - HpDTBS + Mg + phosphoaminophosphonic acid | **[[3qxs]] - HpDTBS + Mg + phosphoaminophosphonic acid<br /> | ||
**[[6cvf]] - MtDTBS + Mg + CDP<br /> | |||
*DTBS quaternary complex | *DTBS quaternary complex | ||
| Line 42: | Line 54: | ||
**[[1a82]] - EcDTBS + DAN + Mg + ATP<BR /> | **[[1a82]] - EcDTBS + DAN + Mg + ATP<BR /> | ||
**[[3fpa]] - MtDTBS + DTB + Mg + phosphate <br /> | **[[3fpa]] - MtDTBS + DTB + Mg + phosphate <br /> | ||
**[[6cve]] - MtDTBS + Mg + aminopelargonic acid + CTP<br /> | |||
**[[3mle]] - HpDTBS + Mg + phosphate + ADP<BR /> | **[[3mle]] - HpDTBS + Mg + phosphate + ADP<BR /> | ||
**[[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR /> | **[[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR /> | ||
Revision as of 12:23, 5 June 2019
Dethiobiotin synthetase (DTBS) or ATP-depenent dethiobiotin synthetase catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.[1] Structural highlightsThe .[2] 3D dethiobiotin synthetaseDethiobiotin synthetase 3D structures
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3D dethiobiotin synthetase3D dethiobiotin synthetase
Updated on 05-June-2019
ReferencesReferences
- ↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
- ↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910