Hyaluronidase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
HU structure contains an <scene name='49/497055/Cv/2'>N-terminal, linker and C-terminal domains</scene>. The active site is in a cleft in the N-terminal domain.  Two HUA molecules are bound in the active site making contacts with some HU residues and multiple contacts with water molecules<ref>PMID:10843845</ref>.
HU structure contains an <scene name='49/497055/Cv/8'>N-terminal, linker and C-terminal domains</scene>. The active site is in a cleft in the N-terminal domain.  Two HUA molecules are bound in the active site making contacts with some HU residues and multiple contacts with water molecules<ref>PMID:10843845</ref>.


<scene name='49/497055/Cv/5'>1st active site of HU</scene>. Water molecules shown as red spheres.
<scene name='49/497055/Cv/9'>1st active site of HU</scene>. Water molecules are shown as red spheres.


<scene name='49/497055/Cv/6'>2nd active site of HU</scene>.
<scene name='49/497055/Cv/10'>2nd active site of HU</scene>.


<scene name='49/497055/Cv/7'>Dimethylarsinate binding site</scene>.
<scene name='49/497055/Cv/11'>Dimethylarsinate binding site</scene>.
</StructureSection>
</StructureSection>


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Michal Harel, Alexander Berchansky, Joel L. Sussman