Chromodomain-helicase-DNA-binding protein

Chromodomain-helicase-DNA-binding proteins (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower. CHDs contain several domains such as chromodomain which is found in proteins involved in chromatin remodeling, PHD zinc finger which has Cys4-His-Cys3 motif and BRK domain which is associated with chromodomains. CHD1 - ATP-dependent chromatin-modeling factor. Functions as substrate recognition component of the transcription regulatory acetylation complex SAGA. CHD4 - Chromatin-modeling factor. Functions as component of the transcription regulatory deacetylation complex NuRD. CHD6 - Probable transcription regulator. CHD7 - ATP-dependent chromatin-modeling factor. May be involved in the 45S precursor ribosomal RNA production. CHD8 - acts as transcription repressor by modeling chromatin structure and recruiting histone H1 to target genes. Histone H3 tail peptide contains (PDB entry 2b2u).

spinqualitylabelsall models Tandem chromodomains of human CHD1 (grey, green, pink) complex with histone H3 tail peptide (yellow) containing trimethyllysine and dimethylarginine (PDB entry 2b2u) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of CHD3D structures of CHD

Updated on 12-May-2019

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• CHD1
  • 2b2t – hCHD1 (mutant) + histone H3 tail – human
    
  • 2b2u, 2b2v, 2b2w - hCHD1 + histone H3 tail
    
  • 2b2y - hCHD1 chromodomains
    
  • 4b4c – hCHD1 DNA-binding domain
    
  • 2n39 – hCHD1 C-terminal - NMR
    
  • 4nw2, 4o42 - hCHD1 chromodomains + nonstructural protein
    
  • 5afw - hCHD1 chromodomains + LSD1 peptide
    
• CHD4
  • 2l5u – hCHD4 PHD finger 1 – NMR
    
  • 2l75 - hCHD4 PHD finger 2 + histone H3 peptide – NMR
    
  • 2ee1 – hCHD4 chromodomain – NMR
    
  • 1mm2, 1mm3 - hCHD4 PHD finger 2 – NMR
    
  • 2n5n – hCHD4 N-terminal - NMR
    
  • 4o9i – hCHD4 double chromodomains
    
• CHD6
  • 2epb – hCHD6 chromodomain 2 – NMR
    
• CHD7
  • 2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
    
• CHD8
  • 2dl6, 2cka – hCHD8 BRK domain - NMR