Cadherin: Difference between revisions

Revision as of 13:33, 18 April 2019

Function

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains:
*Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.^[1]

Desmogleins (Des-CDH) are CDH found in desmosomes.

Structural highlights

The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by docking into the hydrophobic pocket of the neighboring CDH molecule. ^[2]

3D Structures of Cadherin

Cadherin 3D structures

ReferencesReferences

↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368

[2] Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

[1]

[2]

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 </StructureSection>
-== 3D Structures of Cadherin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* CDH5
-**[[2koh]] – mCDH5+PAR3-PDZ3 - mouse<br />
-* CDH6
-**[[3lnd]] – mCDH6 EC12 (mutant)<br />
-*CDH encoded by CDH7
-**[[6cgs]] – mCDH7 EC1-EC2<br />
-* CDH8
-**[[1zxk]] – mCDH8 EC1<br />
-**[[2a62]] - mCDH8 EC1-EC3<br />
-* CDH11
-**[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
-**[[6cgb]] - mCDH11 EC1/CDH6 EC2<br />
-* CDH20
-**[[1zvn]] – cCDH20 EC1 – chicken<br />
-*CDH encoded by CDH22
-**[[6cg7]] – mCDH20 EC1-EC2<br />
-* CDH23
-**[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
-**[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
-**[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
-**[[2wbx]] – mCDH23 EC1<br />
-**[[2wcp]] - mCDH23 EC2<br />
-**[[2wd0]] - mCDH23 EC1-EC2 (mutant)<br />
-**[[5w4t]] - CDH23 EC1-EC3 - zebrafish<br />
-**[[5tfm]] - mCDH23 EC6-EC8<br />
-**[[5tfl]] - mCDH23 EC7-EC8<br />
-**[[5vh2]] - mCDH23 EC12-EC13 (mutant)<br />
-**[[5wj8]] - hCDH23 EC13-EC14<br />
-**[[5wjm]] - mCDH23 EC17-EC18<br />
-**[[5tfk]] - mCDH23 EC19-EC21<br />
-**[[5i8d]], [[5ulu]], [[5un2]] - mCDH23 EC19-EC21 (mutant)<br />
-**[[5vvm]] - hCDH23 EC21-EC23<br />
-**[[5uz8]] - mCDH23 EC22-EC24<br />
-**[[5vt8]] - mCDH23 EC23-EC25<br />
-**[[4apx]], [[4aq8]], [[4axw]], [[4xxw]] - mCDH23 EC1-EC2 + Prot-CDH15<br />
-**[[4aqa]], [[4aqe]] - mCDH23 EC1-EC2 (mutant) + Prot-CDH15
-* C-CDH “classical”
-**[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
-**[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
-* E-CDH epithelial or CDH1
-**[[1q1p]], [[1ff5]], [[1edh]], [[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]], [[2qvf]] – mE-CDH EC1-EC2<br />
-**[[3q2v]] – mE-CDH ectodomain<br />
-**[[4zt1]], [[2o72]] – hE-CDH EC1-EC2<br />
-**[[4zte]] – hE-CDH EC1-EC2 + inhibitor<br />
-**[[6fek]] – hE-CDH EC1-EC2 + antibody<br />
-**[[1edh]] - mE-CDH EC1-EC2+Ca<br />
-**[[3q2l]], [[3q2n]], [[3qrb]] - mE-CDH EC1-EC2 (mutant)<br />
-**[[1suh]] – mE-CDH N-terminal - NMR<br />
-**[[1i7x]], [[1i7w]] – mE-CDH cytoplasmic domain +catenin<br />
-**[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
-**[[3ifq]] – hE-CDH EC1-EC3 <br />
-**[[3ff7]], [[3ff8]] - hE-CDH EC1-EC3+NK cell receptor<br />
-**[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
-**[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
-**[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
-*K-CDH kidney or CDH6
-**[[5veb]] – hK-CDH EC5 + antibody<br />
-**[[6cgu]] – mK-CDH EC1-EC2 <br />
-* T-CDH membrane bound
-**[[3k5r]], [[6cg6]] – mT-CDH EC1-EC2<br />
-**[[3k5s]] - cT-CDH EC1-EC2 <br />
-**[[3k6d]] - XlT-CDH EC1 <br />
-**[[3k6f]] - mT-CDH EC1<br />
-**[[3k6i]] - cT-CDH EC1<br />
-**[[2v37]] – hT-CDH N-terminal - NMR<br />
-* N-CDH neuronal
-**[[1nch]], [[1nci]] – mN-CDH<br />
-**[[1ncg]] – mN-CDH (mutant)<br />
-**[[2qvi]], [[4nuq]] – mN-CDH EC1-EC2<br />
-**[[4num]], [[4nup]] – mN-CDH EC1-EC2 (mutant)<br />
-**[[1ncj]] – mN-CDH two domains<br />
-**[[3q2w]] – mN-CDH ectodomain<br />
-**[[1op4]] - mN-CDH prodomain - NMR<br />
-**[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
-**[[3ubh]] - DmN-CDH EC1-EC4<br />
-**[[3ubg]] - DmN-CDH EC1-EC3
-*P-CDH placental or CDH3
-**[[4nqq]] – mP-CDH EC1-EC2<br />
-**[[4oy9]], [[4zml]], [[4zmn]], [[4zmq]], [[4zmt]], [[4zmw]], [[4zmz]] – hP-CDH EC1-EC2<br />
-**[[4zmo]], [[4zmp]], [[4zmv]], [[4zmx]], [[4zmy]] – hP-CDH EC1-EC2 (mutant)<br />
-**[[5jyl]], [[5jym]] – hP-CDH EC1-EC2 + SCFV TSP7<br />
-*VE-CDH vascular epithelial
-**[[3ppe]] – cVE-CDH EC1+EC2<br />
-* Protocadherin
-**[[6bx7]] - hProt-CDH1 EC1-EC4<br />
-**[[2yst]] – hProt-CDH7 EC3 – NMR<br />
-**[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
-**[[1wyj]] - mProt-CDH β 14 - NMR<br />
-**[[1wuz]] - mProt-CDH4 EC1 – NMR<br />
-**[[5cyx]] - mProt-CDH2 EC1+EC2+EC3<br />
-**[[5szl]] - mProt-CDH γ A1 EC1-EC4<br />
-* Desmoglein
-**[[2yqg]] – hDes-CDH2 EC1<br />
-**[[5erd]] – hDes-CDH2 ectodomain<br />
-**[[5eqx]] – hDes-CDH3 ectodomain<br />
-**[[6qnt]], [[6qnu]] – hDesmc2 ectodomain + adenovirus fiber protein – Cryo EM<br />
-*Desmocollin
-**[[5iry]] – hDesmc1 ectodomain<br />
-**[[5erp]], [[5j5j]] – hDesmc2 ectodomain<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]