Glyoxalase

Function Glyoxalase (GLO) is part of the glyoxalase system which detoxifies the highly toxic methylglyoxal and other aldehydes produced by metabolism. GLO1 or lactoylglutathione lyase catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione. GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II. Relevance GLO1 is a target for drugs against bacteria, protozoans and cancer. The GLO system is a focus of research on metabolic control and prevention of vascular complications in diabetes and obesity. Structural highlights . Water molecules are shown as red spheres.

spinqualitylabelsall models Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) 1qin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of glyoxalase3D structures of glyoxalase

Updated on 03-April-2019

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• Glyoxalase 1 or lactoylglutathione lyase
  • 1bh5 – hGLO (mutant) – human
    
  • 1fa8 – EcGLO – Escherichia coli
    
  • 2c21 – GLO – Leishmania major
    
  • 1fro – hGLO + benzyl glutathione
    
  • 1qin, 1qip - hGLO + glutathione derivative
    
  • 3w0u, 3w0t, 3vw9 – hGLO + inhibitor
    
  • 1f9z, 1fa5, 1fa6, 1fa7 – EcGLO + metal
    
  • 2za0 – mGLO + methyl gerfelin – mouse
    
  • 4x2a – mGLO + baicalein
    
  • 4pv5 – mGLO + glycyrrhetinic acid
    
  • 4opn – mGLO + MAH
    
  • 4kyk, 4kyh – mGLO + drug
    
  • 3hdp – GLO + Ni – Clostridium acetobutylicum
    
  • 5d7z – GLO – maize
    
• Glyoxalase 2
  • 1xm8 – GLO – Arabidopsis thaliana
    
  • 2p18 - LiGLO – Leishmania infantum
    
  • 1qh3 – hGLO + actate + cacodylate
    
  • 1qh5 – hGLO + glutathione derivative
    
  • 2p1e – LiGLO + lactate
• Glyoxalase 3
  • 4lru – GLO – Candida albicans