ATPase family AAA domain-containing protein 2: Difference between revisions

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<scene name='80/800695/Cv/3'>Benzimidazol derivative inhibitor binds within ATAD2A bromodomain ε-N-acetyllysine recognition site</scene> on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions<ref>PMID:25314628</ref>. Water molecules are shown as red spheres.
<scene name='80/800695/Cv/3'>Benzimidazol derivative inhibitor binds within ATAD2A bromodomain ε-N-acetyllysine recognition site</scene> on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions<ref>PMID:25314628</ref>. Water molecules are shown as red spheres.
==3D structures of ATPase family AAA domain-containing protein 2==
[[ATPase family AAA domain-containing protein]]


</StructureSection>
</StructureSection>
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*ATAD2A bromodomain residues 981-1108
*ATAD2A bromodomain residues 981-1108


**[[3dai]], [[4tu6]] - hATAD2 - human<br />
**[[3dai]], [[4tu6]], [[6cps]] - hATAD2 - human<br />
**[[4tt6]] - hATAD2 bromodomain (mutant)<br />
**[[4tt6]] - hATAD2 (mutant)<br />
**[[4tyl]], [[4tz2]], [[4tz8]], [[5epb]], [[5f36]], [[5f3a]], [[5lj0]], [[5lj1]], [[5lj2]], [[4qst]], [[5a5n]], [[5a5o]], [[5a5p]], [[4qss]], [[5a5q]], [[5a5r]], [[5a5s]], [[5a81]], [[5a82]], [[5a83]], [[5a85]], [[4tte]], [[4tu4]] - hATAD2 + inhibitor<br />
**[[4tyl]], [[4tz2]], [[4tz8]], [[5epb]], [[5f36]], [[5f3a]], [[5lj0]], [[5lj1]], [[5lj2]], [[4qst]], [[5a5n]], [[5a5o]], [[5a5p]], [[4qss]], [[5a5q]], [[5a5r]], [[5a5s]], [[5a81]], [[5a82]], [[5a83]], [[5a85]], [[4tte]], [[4tu4]], [[6epj]], [[6epr]], [[6eps]], [[6ept]],  [[6epu]], [[6epv]], [[6epw]], [[6epx]], [[6hdn]], [[6hdo]], [[6hi3]], [[6hi4]], [[6hi5]], [[6hi6]], [[6hi7]], [[6hia]], [[6hib]], [[6hic]], [[6hid]], [[6hie]] - hATAD2 + inhibitor<br />
**[[4qsp]] - hATAD2 + acetyl lysine<br />
**[[4qsp]] - hATAD2 + acetyl lysine<br />
**[[4qsq]] - hATAD2 + DMSO<br />
**[[4qsq]] - hATAD2 + DMSO<br />

Revision as of 12:01, 27 March 2019


Function

ATPase family AAA domain-containing protein 2 (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes[1].

Relevance

Overexpression of ATAD2 has been linked to breast cancer[2], hepatocellular carcinoma[3] and lung adenocarcinoma[4].

Structural highlights

on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions[5]. Water molecules are shown as red spheres.

3D structures of ATPase family AAA domain-containing protein 2

ATPase family AAA domain-containing protein


Human ATAD2A bromodomain comples with benzimidazol derivative inhibitor and Cl- ions (green) (PDB code 4tyl)

Drag the structure with the mouse to rotate

3D structures of ATPase family AAA domain-containing protein 23D structures of ATPase family AAA domain-containing protein 2

Updated on 27-March-2019

ReferencesReferences

  1. ↑ Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104
  2. ↑ Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb;8(2):183-93. doi: 10.1158/1541-7786.MCR-09-0095. Epub, 2010 Feb 2. PMID:20124470 doi:http://dx.doi.org/10.1158/1541-7786.MCR-09-0095
  3. ↑ Yang J, Huang J, Luo L, Chen Z, Guo Y, Guo L. Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma. Cancer Cell Int. 2014 Apr 4;14:33. doi: 10.1186/1475-2867-14-33. eCollection, 2014. PMID:24708861 doi:http://dx.doi.org/10.1186/1475-2867-14-33
  4. ↑ Zhang Y, Sun Y, Li Y, Fang Z, Wang R, Pan Y, Hu H, Luo X, Ye T, Li H, Wang L, Chen H, Ji H. ANCCA protein expression is a novel independent poor prognostic marker in surgically resected lung adenocarcinoma. Ann Surg Oncol. 2013 Dec;20 Suppl 3:S577-82. doi: 10.1245/s10434-013-3027-1. Epub, 2013 Jun 18. PMID:23775406 doi:http://dx.doi.org/10.1245/s10434-013-3027-1
  5. ↑ Harner MJ, Chauder BA, Phan J, Fesik SW. Fragment-based screening of the bromodomain of ATAD2. J Med Chem. 2014 Oct 14. PMID:25314628 doi:http://dx.doi.org/10.1021/jm501035j

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Michal Harel, Alexander Berchansky
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