ATPase family AAA domain-containing protein 2

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Function

ATPase family AAA domain-containing protein 2 (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes[1].

Relevance

Overexpression of ATAD2 has been linked to breast cancer[2], hepatocellular carcinoma[3] and lung adenocarcinoma[4].

Structural highlights

on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions[5]. Water molecules are shown as red spheres.

3D structures of ATPase family AAA domain-containing protein 2

ATPase family AAA domain-containing protein


Human ATAD2A bromodomain comples with benzimidazol derivative inhibitor and Cl- ions (green) (PDB code 4tyl)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104
  2. ↑ Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb;8(2):183-93. doi: 10.1158/1541-7786.MCR-09-0095. Epub, 2010 Feb 2. PMID:20124470 doi:http://dx.doi.org/10.1158/1541-7786.MCR-09-0095
  3. ↑ Yang J, Huang J, Luo L, Chen Z, Guo Y, Guo L. Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma. Cancer Cell Int. 2014 Apr 4;14:33. doi: 10.1186/1475-2867-14-33. eCollection, 2014. PMID:24708861 doi:http://dx.doi.org/10.1186/1475-2867-14-33
  4. ↑ Zhang Y, Sun Y, Li Y, Fang Z, Wang R, Pan Y, Hu H, Luo X, Ye T, Li H, Wang L, Chen H, Ji H. ANCCA protein expression is a novel independent poor prognostic marker in surgically resected lung adenocarcinoma. Ann Surg Oncol. 2013 Dec;20 Suppl 3:S577-82. doi: 10.1245/s10434-013-3027-1. Epub, 2013 Jun 18. PMID:23775406 doi:http://dx.doi.org/10.1245/s10434-013-3027-1
  5. ↑ Harner MJ, Chauder BA, Phan J, Fesik SW. Fragment-based screening of the bromodomain of ATAD2. J Med Chem. 2014 Oct 14. PMID:25314628 doi:http://dx.doi.org/10.1021/jm501035j

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