Exotoxin

Function Exotoxins (ET) are toxins which are secreted by Gram-positive and Gram-negative bacteria. ETs are heat labile. They are highly toxic and fatal in μg quantities. ETs bind to specific receptors and have no enzymatic activity. Relevance Exotoxins are involved in tetanus, diphtheria and botulism. Structural highlights in Vibrio cholerae exotoxin (PDB code 3q9o). Water molecules shown as red spheres.

spinqualitylabelsall models Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code 3q9o). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of exotoxin3D structures of exotoxin

Updated on 14-March-2019

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• Pseudomonas aeruginosa exotoxin
  • 1ikq – PaET A
    
  • 1ikp – PaET A (mutant)
    
  • 1dma – PaET A catalytic domain + nicotinamide + AMP
    
  • 1aer – PaET A catalytic domain + NAD analog + AMP
    
  • 1xk9 – PaET A catalytic domain + inhibitor
    
  • 1zm2 – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2
    
  • 1zm3 – PaET A catalytic domain + diphthamide + EF-2
    
  • 3b78, 2zit – PaET A catalytic domain + diphthamide + NAD + EF-2
    
  • 3b82, 3b8h – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2
    
  • 1zm4 – PaET A catalytic domain + diphthamide + NAD analog + EF-2
    
  • 1zm9 – PaET A catalytic domain + diphthamide + inhibitor + EF-2
    
• Vibrio cholerae exotoxin
  • 2q5t – VcET
    
  • 2q6m, 3ess, 3ki0, 3ki1, 3ki2, 3ki3, 3ki4, 3ki5, 3ki6, 3ki7, 3ny6 – VcET catalytic domain + inhibitor
    
  • 3q9o – VcET + NAD
    
• Streptococcus pyogenes exotoxin
  • 1b1z, 1fnu, 1fnv, 1fnw – SpET A1
    
  • 1dki – SpET B
    
  • 2jtc – SpET B (mutant) - NMR
    
  • 1an8 – SpET C
    
  • 1et9 – SpET H
    
  • 2ici – SpET I
    
  • 1ty0 – SpET J
    
  • 1ha5, 1uup – SpET A1 + Zn
    
  • 1l0x – SpET A1 (mutant) + T cell receptor β chain
    
  • 1pvj – SpET B + inhibitor
    
  • 2uzj – SpET B + guanidine derivative
    
  • 1eu4 – SpET H + Zn
    
  • 1ty2 – SpET J + Zn
    
  • 1ktk – SpET C (mutant) + T cell receptor β chain
    
  • 1l0y – SpET A1 (mutant) + T cell receptor β chain + Zn
    
  • 1hqr – SpRT C + antibody + myelin basic protein
    
• Staphylococcus aureus exotoxin
  • 3ury – SaET
    
  • 1v1o, 1v1p – SaET 1
    
  • 2r61, 2z8l – SaET 3
    
  • 3r2i – SaET 5
    
  • 4zys – SaET 6
    
  • 3o13 – SaET 15
    
  • 3kls – SaET 1 (mutant) + complement C5
    
• Corynebacterium diphtheriae exotoxin See Diphtheria toxin