Clp Protease

Function Clp protease (CLP) is a serine peptidase which hydrolyzes proteins in the presence of ATP and Mg+2 ion. CLP is found in mitochondria. CLP participates in degradation of misfolded proteins. For more details see Clp protease Zinc Fingers Molecular Playground/ClpP Molecular Playground/E. coli ClpP. Structural highlights CLP is a heterodimer containing an ATP-binding regulatory subunit A ClpA or Hsp100 in Heat Shock Proteins and catalytic subunit P ClpP. The proteolytic complex is composed of 2 heptameric rings of ClpP flanked by hexameric rings of ClpA. For full proteolytic activity ClpP must associate with one of two related ATPase subunits: ClpA and ClpX.

spinqualitylabelsall models E. coli Clp protease catalytic subunit (PDB entry 1tyf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of Clp protease3D structures of Clp protease

Updated on 17-February-2019

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• CLP P subunit
  • 1tyf, 1yg6 – EcCLP – Escherichia coli
    
  • 1yg8, 3hln - EcCLP (mutant)
    
  • 2ds6 - EcCLP Zinc-binding domain
    
  • 1y7o – CLP – Streptococcus pneumoniae
    
  • 1tg6 - CLP – human
    
  • 2f6i, 4gm2, 4hnk - CLP – Plasmodium falciparum
    
  • 2cby, 2ce3, 2c8t, 4u0h, 5e0s, 5dzk - MtCLP – Mycobacterium tuberculosis
    
  • 3fes - CLP – Clostridium difficile
    
  • 3ktg, 3kth, 3tt6 – BsCLP – Bacillus subtilis
    
  • 3p2l, 5g1s, 5g1r, 5g1q - CLP – Francisella tulerensis
    
  • 3q7h - CLP – Coxiella burnetii
    
  • 3qwd, 3st9, 3sta, 3v5e, 4emm, 4mxi - SaCLP – Staphylococcus aureus
    
  • 3v5i, 4emp, 5c90 - SaCLP (mutant)
    
  • 2zl0 - HpCLP – Helicobacter pylori
    
  • 2zl3 - HpCLP (mutant)
    
  • 4jcq, 4jct, 4ryf – LmCLP – Listeria monocytogenes
    
  • 4jcr - LmCLP (mutant)
    
• CLP P subunit complex
  • 2fzs, 3mt6 - EcCLP + peptide
    
  • 2zl2 - HpCLP + peptide
    
  • 2zl4 - HpCLP (mutant) + peptide
    
  • 3kti, 3ktj, 3ktk - BsCLP + peptide
    
  • 3tt7 - BsCLP + DFP
    
  • 4u0g – MtCLP + ADEP + agonist
    
  • 5dl1 – SaCLP + inhibitor
    
  • 5dkp – CLP + ADEP – Neisseria meningitidis
    
• CLP A subunit and CLP N see Heat Shock Proteins Hsp100