6bo4: Difference between revisions

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'''Unreleased structure'''


The entry 6bo4 is ON HOLD until Paper Publication
==Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain==
 
<StructureSection load='6bo4' size='340' side='right' caption='[[6bo4]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6bo4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BO4 FirstGlance]. <br>
Description:  
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bo5|6bo5]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo4 OCA], [http://pdbe.org/6bo4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bo4 RCSB], [http://www.ebi.ac.uk/pdbsum/6bo4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo4 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT]] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dosey, T L]]
[[Category: Wang, Z]]
[[Category: Cation]]
[[Category: Channel]]
[[Category: Membrane protein]]
[[Category: Open]]
[[Category: Trp]]

Revision as of 09:32, 5 December 2018

Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domainOpen state structure of the full-length TRPV2 cation channel with a resolved pore turret domain

Structural highlights

6bo4 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).[1] [2]

References

  1. ↑ Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999 Apr 1;398(6726):436-41. PMID:10201375 doi:http://dx.doi.org/10.1038/18906
  2. ↑ Stokes AJ, Shimoda LM, Koblan-Huberson M, Adra CN, Turner H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med. 2004 Jul 19;200(2):137-47. Epub 2004 Jul 12. PMID:15249591 doi:http://dx.doi.org/10.1084/jem.20032082

6bo4, resolution 4.00Å

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