Histone methyltransferase: Difference between revisions
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**[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br /> | **[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br /> | ||
**[[5kh6]] - hKHMT SETDB1 tudor domain <br /> | **[[5kh6]] - hKHMT SETDB1 tudor domain <br /> | ||
**[[5tfp]] - hKHMT SETDB2 N-terminal <br /> | |||
**[[2r3a]] – hKHMT Suv39H2<br /> | **[[2r3a]] – hKHMT Suv39H2<br /> | ||
**[[3rq4]] - hKHMT Suv420H2<br /> | **[[3rq4]] - hKHMT Suv420H2<br /> | ||
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**[[4mi0]] – hKHMT Ezh2<br /> | **[[4mi0]] – hKHMT Ezh2<br /> | ||
**[[4mi5]] – hKHMT Ezh2 SET domain<br /> | **[[4mi5]] – hKHMT Ezh2 SET domain<br /> | ||
**[[6by9]] - hKHMT EHMT1 residues 672-999<br /> | |||
**[[5v2n]] - hKHMT KMT5A residues 231-393<br /> | |||
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | **[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | ||
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | **[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | ||
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**[[4pzi]] – hKHMT CxxC domain + DNA <br /> | **[[4pzi]] – hKHMT CxxC domain + DNA <br /> | ||
**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br /> | **[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br /> | ||
**[[5vc8]] - hKHMT Nsd2 + DNA<br /> | |||
**[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br /> | **[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br /> | ||
**[[4ygi]] – AtKHMT Suvh4 + DNA<br /> | **[[4ygi]] – AtKHMT Suvh4 + DNA<br /> | ||
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**[[5th7]] – hKHMT SETD8 + inhibitor <br /> | **[[5th7]] – hKHMT SETD8 + inhibitor <br /> | ||
**[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br /> | **[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br /> | ||
**[[5ke3]], [[5ke2]], [[5kco]], [[5kch]] - hKHMT SETDB1 tudor domain + inhibitor<br /> | **[[5ke3]], [[5ke2]], [[5kco]], [[5kch]], [[6bpi]], [[6au3]], [[6au2]] - hKHMT SETDB1 tudor domain + inhibitor<br /> | ||
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | **[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | ||
**[[4wuy]] - hKHMT Smyd2 + inhibitor<br /> | **[[4wuy]], [[6cby]], [[6cbx]], [[5wcg]] - hKHMT Smyd2 + inhibitor<br /> | ||
**[[5cpr]] - hKHMT Suv420 SET domain + inhibitor<br /> | **[[5cpr]] - hKHMT Suv420 SET domain + inhibitor<br /> | ||
**[[5w1y]] - hKHMT KMT5A SET domain (mutant) + inhibitor<br /> | |||
**[[5wbv]] - hKHMT KMT5B SET domain + inhibitor<br /> | |||
**[[5vsf]], [[5vsd]], [[5vpj]] - hKHMT EHMT1 SET domain + inhibitor<br /> | |||
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br /> | |||
*Histone-lysine N-methyltransferase binary complexes with polypeptide | *Histone-lysine N-methyltransferase binary complexes with polypeptide | ||
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**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | **[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | ||
**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br /> | **[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br /> | ||
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide<br /> | |||
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | **[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | ||
**[[6bhi]], [[6bhh]], [[6bhg]], [[6bhe]], [[6bhd]] - hKHMT SETDB1 tudor domain + H3 peptide<br /> | |||
**[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | **[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | ||
**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | **[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | ||
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br /> | |||
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | **[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | ||
**[[6cko]] - zKHMT + AF-10 - zebrafish<br /> | |||
*Histone-lysine N-methyltransferase other binary complexes | *Histone-lysine N-methyltransferase other binary complexes | ||
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**[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | **[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | ||
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br /> | **[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br /> | ||
**[[5v3h]] – hKHMT Smyd2 (mutant) + SAM + inhibitor<br /> | |||
**[[5v37]] – hKHMT Smyd3 + SAM + inhibitor<br /> | |||
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br /> | **[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br /> | ||
**[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | **[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | ||
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**[[4e47]], [[4jds]], [[4jlg]], [[5ayf]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br /> | **[[4e47]], [[4jds]], [[4jlg]], [[5ayf]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br /> | ||
**[[5ylt]] - hKHMT SET7/9 SET domain + sinefungin + inhibitor<br /> | |||
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br /> | **[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br /> | ||
**[[5tuz]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br /> | **[[5tuz]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br /> | ||
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**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br /> | **[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br /> | ||
**[[5ls6]], [[5hyn]] - hKHMT Ezh2 + polycomb protein + Jarid2 + inhibitor<br /> | **[[5ls6]], [[5hyn]] - hKHMT Ezh2 + polycomb protein + Jarid2 + inhibitor<br /> | ||
**[[6c24]], [[6c23]] - hKHMT Ezh2 + polycomb repressor complex 2 – Cryo EM<br /> | |||
*Histone-arginine N-methyltransferase (Carm1) | *Histone-arginine N-methyltransferase (Carm1) | ||
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**[[5ih3]] – mRHMT 4 + SAH<br /> | **[[5ih3]] – mRHMT 4 + SAH<br /> | ||
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]] – mRHMT 4 + inhibitor<br /> | **[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mRHMT 4 + inhibitor<br /> | ||
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mRHMT 4 + poly(A)-binding protein peptide + inhibitor<br /> | **[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mRHMT 4 + poly(A)-binding protein peptide + inhibitor<br /> | ||
**[[4c04]] – mRHMT 6 + inhibitor<br /> | **[[4c04]] – mRHMT 6 + inhibitor<br /> | ||
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**[[5u4x]] – hRHMT 1 catalytic domain + SAH<br /> | **[[5u4x]] – hRHMT 1 catalytic domain + SAH<br /> | ||
**[[5dxj]] – hRHMT 4 catalytic domain + sinefungin <br /> | **[[5dxj]] – hRHMT 4 catalytic domain + sinefungin <br /> | ||
**[[4ikp]] – hRHMT 4 catalytic domain + purine derivative<br /> | **[[4ikp]], [[6d2l]] – hRHMT 4 catalytic domain + purine derivative<br /> | ||
**[[5egs]] – hRHMT 6 + inhibitor<br /> | **[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hRHMT 6 + inhibitor<br /> | ||
*Histone-arginine N-methyltransferase (Carm1) ternary complex | *Histone-arginine N-methyltransferase (Carm1) ternary complex | ||
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**[[5dx0]], [[5dwq]] – hRHMT 4 catalytic domain + sinefungin + H3 peptide<br /> | **[[5dx0]], [[5dwq]] – hRHMT 4 catalytic domain + sinefungin + H3 peptide<br /> | ||
**[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> | **[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> | ||
**[[4gqb]], [[5fa5]] – hRHMT 5 + | **[[6arv]], [[6arj]] – hRHMT 4 catalytic domain + SAH + inhibitor<br /> | ||
**[[5emm]] – hRHMT 5 + | **[[4gqb]], [[5fa5]] – hRHMT 5 + methylosome protein 50 + H4 peptide<br /> | ||
**[[5eml]] – hRHMT 5 + | **[[5emm]] – hRHMT 5 + methylosome protein 50 + sinefungin<br /> | ||
**[[5emk]], [[5emj]], [[5c9z]] – hRHMT 5 + | **[[5eml]] – hRHMT 5 + methylosome protein 50 + SAM<br /> | ||
**[[4x63]], [[4x61]], [[4x60]] – hRHMT 5 + | **[[5emk]], [[5emj]], [[5c9z]] – hRHMT 5 + methylosome protein 50 + sinefungin + inhibitor<br /> | ||
**[[4x63]], [[4x61]], [[4x60]] – hRHMT 5 + methylosome protein 50 + SAH + inhibitor<br /> | |||
**[[6ckc]] – hRHMT 5 + methylsome protein 50 + inhibitor<br /> | |||
**[[5e8r]], [[4y30]], [[4y2h]] – hRHMT 6 + SAH + inhibitor<br /> | **[[5e8r]], [[4y30]], [[4y2h]] – hRHMT 6 + SAH + inhibitor<br /> | ||
**[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | **[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | ||