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==GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE== | ==GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE== | ||
<StructureSection load='1ump' size='340' side='right' caption='[[1ump]], [[Resolution|resolution]] 2.13Å' scene=''> | <StructureSection load='1ump' size='340' side='right' caption='[[1ump]], [[Resolution|resolution]] 2.13Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h39|1h39]], [[1h3a|1h3a]], [[1h3b|1h3b]], [[1h3c|1h3c]], [[1o6h|1o6h]], [[1o6q|1o6q]], [[1o6r|1o6r]], [[1o79|1o79]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h39|1h39]], [[1h3a|1h3a]], [[1h3b|1h3b]], [[1h3c|1h3c]], [[1o6h|1o6h]], [[1o6q|1o6q]], [[1o6r|1o6r]], [[1o79|1o79]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ump FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ump OCA], [http://pdbe.org/1ump PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ump RCSB], [http://www.ebi.ac.uk/pdbsum/1ump PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ump FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ump OCA], [http://pdbe.org/1ump PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ump RCSB], [http://www.ebi.ac.uk/pdbsum/1ump PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ump ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/um/1ump_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/um/1ump_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ump ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
Revision as of 10:30, 28 March 2018
GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENEGEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe membrane protein squalene-hopene cyclase was cocrystallized with 2-azasqualene and analyzed by X-ray diffraction to 2.13 A resolution. The conformation of this close analog was clearly established, and it agreed with the common textbook presentation. The bound squalene undergoes only small conformational changes during the formation of rings A through D, thus requiring no intermediate. However, ring E formation is hindered by an entropic barrier, which may explain its absence in the steroids. The structure analysis revealed a mobile region between the active center cavity and the membrane, which may melt, opening a passage for squalene and hopene. Conversion of squalene to the pentacarbocyclic hopene.,Reinert DJ, Balliano G, Schulz GE Chem Biol. 2004 Jan;11(1):121-6. PMID:15113001[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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