Squalene-hopene cyclase

Function Squalene-hopene cyclase or oxidosqualene cyclase (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step. Relevance The hopenoids condense lipid membranes and reduce their permeability. Structural highlights The . Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of squalene-hopene cyclase complex with 2-azasqualene and detergent (PDB code 1ump). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of squalene-hopene cyclase3D structures of squalene-hopene cyclase

Updated on 09-November-2020

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• Squalene-hopene cyclase
  • 1sqc – AaSHC – Alicyclobacillus acidocaldarius
    
  • 2sqc, 3sqc – AaSHC (mutant)
    
• Squalene-hopene cyclase complexes
  • 1gsz – AaSHC + drug
    
  • 1h35, 1h36, 1h37, 1h39, 1h3a, 1h3b, 1h3c, 1o6h, 1o6q, 1o6r, 1o79 – AaSHC + inhibitor
    
  • 1ump – AaSHC + 2-azasqualene