Cell death protein: Difference between revisions
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<StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> | <StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> | ||
'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref> | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of cell death protein== | ==3D structures of cell death protein== | ||
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**[[5gqq]] - hCED-6 + heme-binding protein<br /> | **[[5gqq]] - hCED-6 + heme-binding protein<br /> | ||
*CED-8 | *CED-8 (apoptosis-inducing factor 1) | ||
**[[1gv4]] - mCED-8<br /> | **[[1gv4]], [[3gd3]] - mCED-8<br /> | ||
**[[1m6i]] - hCED-8<br /> | **[[3gd4]] – mCED-8 + NAD <br /> | ||
**[[5miu]] – mCED-8 (mutant) + FAD <br /> | |||
**[[5miv]] – mCED-8 (mutant) + FAD + NAD<br /> | |||
**[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br /> | |||
**[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant) <br /> | |||
**[[5fs9]] – hCED-8 (mutant) + FAD<br /> | |||
**[[4bur]] – hCED-8 + NAD <br /> | |||
*CED-9 | *CED-9 | ||