5nn8: Difference between revisions
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==Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose== | |||
<StructureSection load='5nn8' size='340' side='right' caption='[[5nn8]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nn8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NN8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACR:ALPHA-ACARBOSE'>ACR</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nn3|5nn3]], [[5nn4|5nn4]], [[5nn5|5nn5]], [[5nn6|5nn6]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn8 OCA], [http://pdbe.org/5nn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nn8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nn8 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/LYAG_HUMAN LYAG_HUMAN]] Glycogen storage disease due to acid maltase deficiency, infantile onset;Glycogen storage disease due to acid maltase deficiency, juvenile onset;Glycogen storage disease due to acid maltase deficiency, adult onset. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LYAG_HUMAN LYAG_HUMAN]] Essential for the degradation of glygogen to glucose in lysosomes. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alpha-glucosidase]] | |||
[[Category: Bourne, Y]] | |||
[[Category: Cobucci-Ponzano, B]] | |||
[[Category: Ferrara, M C]] | |||
[[Category: Germany, S]] | [[Category: Germany, S]] | ||
[[Category: Iacono, R]] | [[Category: Iacono, R]] | ||
[[Category: Moracci, M]] | |||
[[Category: Parenti, G]] | |||
[[Category: Roig-Zamboni, V]] | [[Category: Roig-Zamboni, V]] | ||
[[Category: | [[Category: Glycogen catabolism]] | ||
[[Category: | [[Category: Glycoside hydrolase]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Lysosome]] | ||
[[Category: Pompe disease]] | |||
Revision as of 10:13, 25 October 2017
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarboseCrystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose
Structural highlights
Disease[LYAG_HUMAN] Glycogen storage disease due to acid maltase deficiency, infantile onset;Glycogen storage disease due to acid maltase deficiency, juvenile onset;Glycogen storage disease due to acid maltase deficiency, adult onset. The disease is caused by mutations affecting the gene represented in this entry. Function[LYAG_HUMAN] Essential for the degradation of glygogen to glucose in lysosomes. |
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