4x30: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution== | ==Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution== | ||
<StructureSection load='4x30' size='340' side='right' caption='[[4x30]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='4x30' size='340' side='right' caption='[[4x30]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
| Line 4: | Line 5: | ||
<table><tr><td colspan='2'>[[4x30]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X30 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4x30]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X30 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x30 OCA], [http://pdbe.org/4x30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x30 RCSB], [http://www.ebi.ac.uk/pdbsum/4x30 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x30 OCA], [http://pdbe.org/4x30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x30 RCSB], [http://www.ebi.ac.uk/pdbsum/4x30 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x30 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
Revision as of 12:54, 18 October 2017
Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolutionCrystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
Structural highlights
Disease[THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. Function[THBG_HUMAN] Major thyroid hormone transport protein in serum. |
| ||||||||||||||||