TRAIL: Difference between revisions
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<StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'> | <StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'> | ||
== Function == | == Function == | ||
'''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. <scene name='48/480878/Cv/1'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/2'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>. | '''TRAIL (TNF-related apoptosis-inducing ligand)''' or '''TNF ligand superfamily 10''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. <scene name='48/480878/Cv/1'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/2'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>. | ||
== Disease == | == Disease == | ||
TRAIL concentrations are reduced in rheumatoid | TRAIL concentrations are reduced in rheumatoid arthritis<ref>PMID:25962765</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of TRAIL == | == 3D Structures of TRAIL == | ||
[[1d0g]], [[1d4v]], [[1du3]] - hTRAIL | [[1d0g]], [[1d4v]], [[1du3]], [[5cir]] - hTRAIL extracellular domain + DR5 extracellular domain - human<br /> | ||
[[1dg6]] – hTRAIL jelly-roll domain<br /> | [[1dg6]] – hTRAIL jelly-roll domain<br /> | ||
[[1d2q]] - hTRAIL extracellular domain | [[1d2q]] - hTRAIL extracellular domain<br /> | ||
[[4n90]] - hTRAIL extracellular domain + DR5 extracellular domain + antibody<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 01:05, 11 October 2017
FunctionTRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10 functions as a ligand in the process of apoptosis[1]. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL. (1d0g). . DiseaseTRAIL concentrations are reduced in rheumatoid arthritis[2]. |
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3D Structures of TRAIL3D Structures of TRAIL
1d0g, 1d4v, 1du3, 5cir - hTRAIL extracellular domain + DR5 extracellular domain - human
1dg6 – hTRAIL jelly-roll domain
1d2q - hTRAIL extracellular domain
4n90 - hTRAIL extracellular domain + DR5 extracellular domain + antibody
ReferencesReferences
- ↑ Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311
- ↑ Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765