Histone methyltransferase: Difference between revisions
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**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> | **[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> | ||
*Histone-lysine N-methyltransferase ternary complex | *Histone-lysine N-methyltransferase ternary complex containing polypeptide | ||
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br /> | **[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br /> | ||
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**[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br /> | **[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br /> | ||
**[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br /> | **[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br /> | ||
**[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br /> | **[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br /> | ||
**[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br /> | **[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br /> | ||
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**[[3m54]], [[3m55]], [[3m56]], [[3m57]], [[3m58]], [[3m59]], [[3m5a]] - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide<br /> | **[[3m54]], [[3m55]], [[3m56]], [[3m57]], [[3m58]], [[3m59]], [[3m5a]] - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide<br /> | ||
**[[3cbm]] - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide<br /> | **[[3cbm]] - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide<br /> | ||
**[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br /> | **[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br /> | ||
**[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br /> | **[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br /> | ||
**[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br /> | **[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br /> | ||
**[[5jj0]], [[5jiy]], [[5jin]], [[5jhn]] - hKHMT EHMT2 SET domain + SAM + H3 peptide<br /> | **[[5jj0]], [[5jiy]], [[5jin]], [[5jhn]] - hKHMT EHMT2 SET domain + SAM + H3 peptide<br /> | ||
**[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | **[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | ||
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br /> | **[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br /> | ||
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br /> | **[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br /> | ||
**[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | **[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | ||
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br /> | **[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br /> | ||
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**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br /> | **[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br /> | ||
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br /> | **[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br /> | ||
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | **[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | ||
**[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | **[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | ||
**[[4au7]] - mKHMT + SAH + H4 peptide - mouse<br /> | **[[4au7]] - mKHMT + SAH + H4 peptide - mouse<br /> | ||
*Histone-lysine N-methyltransferase ternary complex containing inhibitor | |||
**[[4e47]], [[4jds]], [[4jlg]], [[5ayf]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br /> | |||
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br /> | |||
**[[5tuz]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br /> | |||
**[[5ttg]] - hKHMT EHMT1 catalytic domain + SAM + inhibitor<br /> | |||
**[[5tuy]] - hKHMT EHMT2 SET domain + SAM + inhibitor<br /> | |||
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br /> | |||
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br /> | |||
**[[5ccm]], [[5ccl]] – hKHMT Smyd3 + SAM + inhibitor<br /> | |||
**[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | |||
**[[4qen]], [[4qeo]], [[4qep]] – AtKHMT Suvh4 + DNA + SAH<br /> | |||
*Histone-lysine N-methyltransferase higher complexes | *Histone-lysine N-methyltransferase higher complexes | ||
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**[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | **[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | ||
**[[4c03]], [[4c06]], [[4c07]], [[4c08]], [[5hzm]] – mRHMT 6<br /> | |||
**[[2obq]] – rRHMT N terminal - rat <br /> | |||
**[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | |||
**[[4qqk]] – hRHMT 6 <br /> | |||
**[[4hc4]] – hRHMT 6 (mutant)<br /> | |||
*Histone-arginine N-methyltransferase (Carm1) binary complex | |||
**[[5ih3]] – mRHMT 4 + SAH<br /> | **[[5ih3]] – mRHMT 4 + SAH<br /> | ||
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]] – mRHMT 4 + inhibitor<br /> | **[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]] – mRHMT 4 + inhibitor<br /> | ||
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mRHMT 4 + poly(A)-binding | **[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mRHMT 4 + poly(A)-binding protein peptide + inhibitor<br /> | ||
**[[4c04]] – mRHMT 6 + inhibitor<br /> | **[[4c04]] – mRHMT 6 + inhibitor<br /> | ||
**[[4c05]], [[5fqo]], [[5fqn]] – mRHMT 6 + SAH<br /> | **[[4c05]], [[5fqo]], [[5fqn]] – mRHMT 6 + SAH<br /> | ||
**[[4c4a]] – mRHMT 7 + SAH<br /> | **[[4c4a]] – mRHMT 7 + SAH<br /> | ||
**[[3b3f]] – rRHMT catalytic domain + SAH<br /> | **[[3b3f]] – rRHMT catalytic domain + SAH<br /> | ||
**[[5u4x]] – hRHMT 1 catalytic domain + SAH<br /> | **[[5u4x]] – hRHMT 1 catalytic domain + SAH<br /> | ||
**[[5dxj]] – hRHMT 4 catalytic domain + sinefungin <br /> | **[[5dxj]] – hRHMT 4 catalytic domain + sinefungin <br /> | ||
**[[4ikp]] – hRHMT 4 catalytic domain + purine derivative<br /> | |||
**[[5egs]] – hRHMT 6 + inhibitor<br /> | |||
*Histone-arginine N-methyltransferase (Carm1) ternary complex | |||
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mRHMT 4 + poly(A)-binding protein peptide + inhibitor<br /> | |||
**[[5dxa]], [[5dx8]], [[5dx1]] – hRHMT 4 catalytic domain + sinefungin + peptide<br /> | **[[5dxa]], [[5dx8]], [[5dx1]] – hRHMT 4 catalytic domain + sinefungin + peptide<br /> | ||
**[[5dx0]], [[5dwq]] – hRHMT 4 catalytic domain + sinefungin + H3 peptide<br /> | **[[5dx0]], [[5dwq]] – hRHMT 4 catalytic domain + sinefungin + H3 peptide<br /> | ||
**[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> | **[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> | ||
**[[4gqb]], [[5fa5]] – hRHMT 5 + methylsome protein 50 + H4 peptide<br /> | **[[4gqb]], [[5fa5]] – hRHMT 5 + methylsome protein 50 + H4 peptide<br /> | ||
**[[5emm]] – hRHMT 5 + methylsome protein 50 + sinefungin<br /> | **[[5emm]] – hRHMT 5 + methylsome protein 50 + sinefungin<br /> | ||
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**[[5emk]], [[5emj]], [[5c9z]] – hRHMT 5 + methylsome protein 50 + sinefungin + inhibitor<br /> | **[[5emk]], [[5emj]], [[5c9z]] – hRHMT 5 + methylsome protein 50 + sinefungin + inhibitor<br /> | ||
**[[4x63]], [[4x61]], [[4x60]] – hRHMT 5 + methylsome protein 50 + SAH + inhibitor<br /> | **[[4x63]], [[4x61]], [[4x60]] – hRHMT 5 + methylsome protein 50 + SAH + inhibitor<br /> | ||
**[[5e8r]], [[4y30]], [[4y2h]] – hRHMT 6 + SAH + inhibitor<br /> | **[[5e8r]], [[4y30]], [[4y2h]] – hRHMT 6 + SAH + inhibitor<br /> | ||
**[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | **[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | ||
Revision as of 10:34, 14 June 2017
FunctionHistone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones[1]. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. RelevanceInhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs[2]. DiseaseAberrant HMT plays a role in cancer, intellectual disability syndromes and regulation of tissue aging[3]. Structural highlightsHuman inserted in a hydrophobic environment[4]. Water molecules shown as red spheres |
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3D Structures of histone methyltransferase3D Structures of histone methyltransferase
Updated on 14-June-2017
ReferencesReferences
- ↑ Trievel RC. Structure and function of histone methyltransferases. Crit Rev Eukaryot Gene Expr. 2004;14(3):147-69. PMID:15248813
- ↑ Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N. Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure. 2011 Jul 20. PMID:21782458 doi:10.1016/j.str.2011.06.011
- ↑ Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173. PMID:22473383 doi:http://dx.doi.org/10.1038/nrg3173
- ↑ Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003 Feb 6;421(6923):652-6. Epub 2003 Jan 22. PMID:12540855 doi:10.1038/nature01378