BRCA: Difference between revisions

Revision as of 12:30, 27 April 2017

Function

BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see RING Finger Domain of BRCA1 and BARD1 Heterodimer.

Disease

Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers^[1].

Structural highlights

The . These domains contain most of the mutations seen in BRCA1^[2]. .

Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj)

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3D structures of BRCA13D structures of BRCA1

Updated on 27-April-2017

4ofb, 4y18, 4y2g, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
1jnx - hBRCA1 BRCT domain
2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
1oqa - hBRCA1 BRCT-C domain - NMR
1l0b - BRCA1 BRCT domain - rat
2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR

ReferencesReferences

↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

[1] Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425

[2] Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m

[1]

[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='3coj' size='340' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains (turqouis) complex with phosphopeptide (red) (PDB code [[3coj]]) ' scene=''>
+<StructureSection load='3coj' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/3' pspeed='8'>
 == Function ==
@@ Line 8: / Line 8: @@
 == Structural highlights ==
-The phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>.
+The <scene name='75/750267/Cv/1'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/2'>Phosphoserine binding</scene>.
 </StructureSection>