Poliovirus receptor-related protein: Difference between revisions

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**[[4myw]], [[3u82]], [[3sku]] – hPVRP1 + envelope glycoprotein D – human<br />
**[[4myw]], [[3u82]], [[3sku]] – hPVRP1 + envelope glycoprotein D – human<br />
**[[4fmf]], [[3u83]], [[3alp]] – hPVRP1 domains D1-D3 <br />
**[[4fmf]], [[3u83]], [[3alp]] – hPVRP1 domains D1-D3 <br />
**[[5b21]] – mPVRP1 domain D1 - mouse<br />
**[[2l7j]] – hPVRP1 domain D3 - NMR<br />
**[[2l7j]] – hPVRP1 domain D3 - NMR<br />


Line 25: Line 26:
**[[4hza]], [[4dfh]], [[3r0n]] – hPVRP2 domain D1<br />
**[[4hza]], [[4dfh]], [[3r0n]] – hPVRP2 domain D1<br />
**[[4dfi]] – hPVRP2 domain D1 (mutant)<br />
**[[4dfi]] – hPVRP2 domain D1 (mutant)<br />
**[[4fmk]], [[4fn0]] – mPVRP2 domains D1-D2 - mouse <br />
**[[4fmk]], [[4fn0]] – mPVRP2 domains D1-D2 <br />
**[[4fs0]] – mPVRP2 domains D1-D2 (mutant) <br />
**[[4fs0]] – mPVRP2 domains D1-D2 (mutant) <br />


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**[[4fom]] – hPVRP3 domains D1-D3 <br />
**[[4fom]] – hPVRP3 domains D1-D3 <br />
**[[5b22]] – mPVRP3 domains D1-D2 <br />


* Poliovirus receptor-related protein 4
* Poliovirus receptor-related protein 4

Revision as of 14:24, 31 January 2017


Function

Poliovirus receptor-related protein (PVRP) or Nectin are membrane glycoproteins belonging to the immunoglobulin family.

  • PVRP-1 mediates Ca+2-independent cell adhesion[1].
  • PVRP-2 and PVRP-3 are components of the adherens junction[2].
  • PVRP-4 binds PVRP-1.

Relevance

PVRP-4 is involved in tumor cell migration.


Poliovirus receptor-related protein 1 (green) complex with herpes virus envelope glycoprotein (grey) (PDB code 4myw)

Drag the structure with the mouse to rotate

3D structures of poliovirus receptor-related protein3D structures of poliovirus receptor-related protein

Updated on 31-January-2017

    • 4myw, 3u82, 3sku – hPVRP1 + envelope glycoprotein D – human
    • 4fmf, 3u83, 3alp – hPVRP1 domains D1-D3
    • 5b21 – mPVRP1 domain D1 - mouse
    • 2l7j – hPVRP1 domain D3 - NMR
  • Poliovirus receptor-related protein 2
    • 4hza, 4dfh, 3r0n – hPVRP2 domain D1
    • 4dfi – hPVRP2 domain D1 (mutant)
    • 4fmk, 4fn0 – mPVRP2 domains D1-D2
    • 4fs0 – mPVRP2 domains D1-D2 (mutant)
  • Poliovirus receptor-related protein 3
    • 4fom – hPVRP3 domains D1-D3
    • 5b22 – mPVRP3 domains D1-D2
  • Poliovirus receptor-related protein 4
    • 4jjh – hPVRP4 domain D1
    • 4gjt – hPVRP4 domain D1 + hemagglutinin glycoprotein
    • 4frw – hPVRP4 domains D1-D2

ReferencesReferences

  1. ↑ Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science. 1998 Jun 5;280(5369):1618-20. PMID:9616127
  2. ↑ Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood. 1998 Dec 15;92(12):4602-11. PMID:9845526

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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