Thrombospondin: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='1za4' size='340' side='right' caption=' | <StructureSection load='1za4' size='340' side='right' caption='Human TSP-1 Nterminal complex with Arixtra heparin (PDB code [[1za4]])' scene=''> | ||
| Line 12: | Line 12: | ||
== Structural highlights == | == Structural highlights == | ||
The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The arginine side chains of the N-terminal interact with the heparin sulfate groups<ref>PMID:16407063</ref>. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 10:56, 21 December 2016
FunctionThrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues[1]. RelevanceTSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments[2]. DiseaseTSP-2 mutation is associated with coronary artery disease[3]. Structural highlightsThe N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The arginine side chains of the N-terminal interact with the heparin sulfate groups[4].
|
| ||||||||||
3D structures of thrombospondin3D structures of thrombospondin
Updated on 21-December-2016
ReferencesReferences
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
- ↑ Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017