Thrombospondin

Function

Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues^[1].

Relevance

TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments^[2].

Disease

TSP-2 mutation is associated with coronary artery disease^[3].

Structural highlights

The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The ^[4].

3D structures of thrombospondin3D structures of thrombospondin

Updated on 19-August-2024

ReferencesReferences

↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
↑ Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800

[2] Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627

[3] Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200

[4] Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017

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