Thrombospondin: Difference between revisions
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== Relevance == | == Relevance == | ||
TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | ||
== Disease == | |||
TSP-2 mutation is associated with coronary artery disease<ref>PMID:18499674</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
Revision as of 14:55, 20 December 2016
FunctionThrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues[1]. RelevanceTSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments[2]. DiseaseTSP-2 mutation is associated with coronary artery disease[3]. Structural highlights |
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3D structures of thrombospondin3D structures of thrombospondin
Updated on 20-December-2016
ReferencesReferences
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200