1pan: Difference between revisions
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|PDB= 1pan |SIZE=350|CAPTION= <scene name='initialview01'>1pan</scene> | |PDB= 1pan |SIZE=350|CAPTION= <scene name='initialview01'>1pan</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1pao|1PAO]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pan OCA], [http://www.ebi.ac.uk/pdbsum/1pan PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pan RCSB]</span> | |||
}} | }} | ||
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[[Category: Mcinnes, C.]] | [[Category: Mcinnes, C.]] | ||
[[Category: Sykes, B D.]] | [[Category: Sykes, B D.]] | ||
[[Category: fimbrial protein]] | [[Category: fimbrial protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:57:11 2008'' | ||
Revision as of 22:57, 30 March 2008
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| Related: | 1PAO
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
A COMPARISON OF NMR SOLUTION STRUCTURES OF THE RECEPTOR BINDING DOMAINS OF PSEUDOMONAS AERUGINOSA PILI STRAINS PAO, KB7, AND PAK: IMPLICATIONS FOR RECEPTOR BINDING AND SYNTHETIC VACCINE DESIGN
OverviewOverview
The solution structures of peptide antigens from the receptor binding domains of Pseudomonas aeruginosa strains PAO and KB7 have been determined using two-dimensional 1H NMR techniques. Ensembles of solution conformations for the trans forms of these 17-residue disulfide-bridged peptides have been generated using a simulated annealing procedure in conjunction with distance and torsion angle restraints derived from NMR data. Comparison of the NMR-derived solution structures of the PAO and KB7 peptides, with that previously determined (McInnes et al., 1993) and herein refined for the PAK peptide reveals a common structural motif. All three peptide structures contain a type I beta-turn in the conserved sequence Asp134-X-X-Phe137 and a type II beta-turn in the conserved sequence Pro139-X-Gly-Cys142. However, the overall folds of the three peptides differ as well as the disposition of the side chains comprising the hydrophobic pockets. The similarities and differences between the structures of the three strains which bind to a common cell surface receptor are discussed in light of their contributions to synthetic vaccine design.
About this StructureAbout this Structure
1PAN is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
ReferenceReference
Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design., Campbell AP, McInnes C, Hodges RS, Sykes BD, Biochemistry. 1995 Dec 19;34(50):16255-68. PMID:8845350
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