Pseudouridine synthase: Difference between revisions
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'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu). '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme. | <StructureSection load='1ze2' size='340' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate [[1ze2]]' scene=''> | ||
== Function == | |||
'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu). '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme. | |||
== Structural highlights == | |||
The conversion of uridine to pseudouridine causes conformational change of PUS<ref>PMID:14990747</ref>. | |||
</StructureSection> | |||
== 3D Structures of tRNA pseudouridine synthase== | == 3D Structures of tRNA pseudouridine synthase== | ||
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**[[1z2z]] – PPUS D – ''Methanosarcina mazei''<br /> | **[[1z2z]] – PPUS D – ''Methanosarcina mazei''<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:35, 25 September 2016
FunctiontRNA pseudouridine synthase (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine[1]. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu). Probable tRNA pseudouridine synthase (PPUS) is a similar enzyme. Structural highlightsThe conversion of uridine to pseudouridine causes conformational change of PUS[2]. |
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3D Structures of tRNA pseudouridine synthase3D Structures of tRNA pseudouridine synthase
Updated on 25-September-2016
ReferencesReferences
- ↑ Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM. Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12648-53. Epub 2003 Oct 17. PMID:14566049 doi:10.1073/pnas.2135585100
- ↑ Phannachet K, Huang RH. Conformational change of pseudouridine 55 synthase upon its association with RNA substrate. Nucleic Acids Res. 2004 Feb 27;32(4):1422-9. Print 2004. PMID:14990747 doi:10.1093/nar/gkh287