Transcription initiation factor: Difference between revisions
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<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | <StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''> | ||
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process.<br /> | '''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br /> | ||
* '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br /> | * '''TFIIA''' is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br /> | ||
* '''TFIIB''' bridges between TFIID and RNA polymerase II.<br /> | * '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br /> | ||
* '''TFIID''' recognizes the promoter sequence on the DNA.<br /> | * '''TFIID''' recognizes the promoter sequence on the DNA.<br /> | ||
* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br /> | |||
* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. | * '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. | ||
</StructureSection> | </StructureSection> | ||
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== References == | |||
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[[Category:Topic Page]] | [[Category:Topic Page]] |