Transcription initiation factor: Difference between revisions

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<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''>
<StructureSection load='1vol' size='400' side='right' caption='Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene=''>


'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process.<br />
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
*  '''TFIIA''' is one of several TFs which are required for transcription.  TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />
*  '''TFIIA''' is one of several TFs which are required for transcription.  TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA.<br />
*  '''TFIIB''' bridges between TFIID and RNA polymerase II.<br />
*  '''TFIIB''' bridges between TFIID and RNA polymerase II<ref>PMID:1876184</ref>.<br />
*  '''TFIID''' recognizes the promoter sequence on the DNA.<br />
*  '''TFIID''' recognizes the promoter sequence on the DNA.<br />
*  '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
*  '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.
*  '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.
</StructureSection>
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== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky, Joel L. Sussman