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==Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah== | ==Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah== | ||
<StructureSection load='3plc' size='340' side='right' caption='[[3plc]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='3plc' size='340' side='right' caption='[[3plc]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3plc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PLC FirstGlance]. <br> | <table><tr><td colspan='2'>[[3plc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PLC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3plc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3plc RCSB], [http://www.ebi.ac.uk/pdbsum/3plc PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3plc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plc OCA], [http://pdbe.org/3plc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3plc RCSB], [http://www.ebi.ac.uk/pdbsum/3plc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3plc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ | [[http://www.uniprot.org/uniprot/3FBC7_OPHHA 3FBC7_OPHHA]] Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2). It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).<ref>PMID:17616557</ref> | ||
==See Also== | ==See Also== | ||
Revision as of 16:39, 5 August 2016
Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannahCrystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah
Structural highlights
Function[3FBC7_OPHHA] Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2). It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).[1] See AlsoReferences
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