Cardiotoxin

Function

Cardiotoxin or cytotoxin (CTX) is a snake toxin from the Taiwan cobra Naja naja. The cardiotoxin from the Malayan krait is called bucain. CTX perturb the membrane structure of cells by interaction with lipids. ^[1] For toxins in Proteopedia see Toxins.

Relevance

Cardiotoxin I causes necrosis of skeletal muscle cells.

Cardiotoxin III induces apoptosis in K562 cells.

3D Structures of Cardiotoxin

Cardiotoxin 3D structures

ReferencesReferences

↑ Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200

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