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==Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)== | ==Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)== | ||
<StructureSection load='4c45' size='340' side='right' caption='[[4c45]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='4c45' size='340' side='right' caption='[[4c45]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C45 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [http://www.ebi.ac.uk/pdbsum/4c45 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [http://pdbe.org/4c45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [http://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 12: | Line 13: | ||
</StructureSection> | </StructureSection> | ||
[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]] | [[Category: 4a-hydroxytetrahydrobiopterin dehydratase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 13:45, 5 August 2016
Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)
Structural highlights
Function[PHS2_HUMAN] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. |
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