4c45

Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)

Structural highlights

4c45 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PHS2_HUMAN Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

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OCA