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==TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant==
==TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant==
<StructureSection load='3mxm' size='340' side='right' caption='[[3mxm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3mxm' size='340' side='right' caption='[[3mxm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mxm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mxm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oa8|2oa8]], [[2ioc|2ioc]], [[3mxi|3mxi]], [[3mxj|3mxj]], [[3mxk|3mxk]], [[3n0o|3n0o]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oa8|2oa8]], [[2ioc|2ioc]], [[3mxi|3mxi]], [[3mxj|3mxj]], [[3mxk|3mxk]], [[3n0o|3n0o]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trex1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trex1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_III Exodeoxyribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.2 3.1.11.2] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_III Exodeoxyribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.2 3.1.11.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxm RCSB], [http://www.ebi.ac.uk/pdbsum/3mxm PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxm OCA], [http://pdbe.org/3mxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxm RCSB], [http://www.ebi.ac.uk/pdbsum/3mxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</StructureSection>
</StructureSection>
[[Category: Exodeoxyribonuclease III]]
[[Category: Exodeoxyribonuclease III]]
[[Category: Mus musculus]]
[[Category: Lk3 transgenic mice]]
[[Category: Bailey, S L]]
[[Category: Bailey, S L]]
[[Category: Hollis, T]]
[[Category: Hollis, T]]

Revision as of 04:39, 5 August 2016

TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome MutantTREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant

Structural highlights

3mxm is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:Trex1 (LK3 transgenic mice)
Activity:Exodeoxyribonuclease III, with EC number 3.1.11.2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TREX1_MOUSE] Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.[1] [2]

See Also

References

  1. ↑ Mazur DJ, Perrino FW. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60. PMID:10391904
  2. ↑ Mazur DJ, Perrino FW. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. J Biol Chem. 2001 May 18;276(20):17022-9. Epub 2001 Mar 6. PMID:11279105 doi:http://dx.doi.org/10.1074/jbc.M100623200

3mxm, resolution 1.75Å

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