Profilin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''> | <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''> | ||
== Function == | == Function == | ||
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. | '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes. | ||
== Disease == | == Disease == | ||
PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>. | PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>. | ||
</StructureSection> | </StructureSection> | ||