Obscurin: Difference between revisions
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'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | '''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | ||
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril<ref>PMID:17012262</ref>. | ||
For more details see [[Group:MUZIC:Obscurin]]. | |||
==3D structures of obscurin== | ==3D structures of obscurin== | ||
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**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | **[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||