NAD(P) transhydrogenase

NAD(P) transhydrogenase (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See NAD and NAD(P)H. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change. PTH uses FAD as cofactor. Structural highlights PTH is composed of 3 domains: Domain I binds NAD(+)/NADH. Domain II is a membrane-spanning domain. Domain III binds NADP(+)/NADPH. PTH is composed of 2 subunits. Subunit beta contains domain III and part of II.

spinqualitylabelsall models Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry 1u28) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of NAD(P) transhydrogenase3D structures of NAD(P) transhydrogenase

Updated on 04-May-2016

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• NAD(P) transhydrogenase domain I
  • 1l7d – RrPTH domain I – Rhodospirillum rubrum
    
  • 1l7e – RrPTH domain I + NAD
    
  • 1x13 – EcPTH domain I – Escherichia coli
    
  • 1x14, 1x15 – EcPTH domain I + NAD
    
  • 4dio – PTH domain I – Sinorhizobium meliloti
    
• PTH domain II
  • 4o93, 4o9p, 4o9t, 4o9u – TtPTH domain II – Thermus thermophilus
    
• NAD(P) transhydrogenase domain III
  • 1e3t – RrPTH domain III + NADP - NMR
    
  • 1pno – RrPTH domain III + NADP
    
  • 1pnq – RrPTH domain III + NADPH
    
  • 1d4o – bPTH domain III + NADP - bovine
    
  • 1djl, 1u31 – hPTH domain III + NADP - human
    
  • 1pt9 – hPTH domain III + NADP analog
    
• NAD(P) transhydrogenase domain I+III
  • 1hzz, 1u28, 1u2d, 1xlt – RrPTH domain I+III + NADP + NAD
    
  • 1f8g – RrPTH domain I+III + NAD
    
  • 1nm5, 2fr8, 2fsv – RrPTH domain I+III (mutant) + NADP + NAD
    
  • 1ptj, 1u2g, 2frd, 2oo5 – RrPTH domain I+III + NADP + NAD derivative
    
  • 2oor – RrPTH domain I+III + NADP derivative + NAD
    
  • 2bru – EcPTH domain I+III + NADP + NAD - NMR
    
  • 4j16, 4j1t – TtPTH domain I+III + NADP + NAD