Methylesterase: Difference between revisions
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{{STRUCTURE_3uw0| PDB=3uw0 | SIZE=400| SCENE= |right|CAPTION=Pectin methylesterase [[3uw0]] }} | {{STRUCTURE_3uw0| PDB=3uw0 | SIZE=400| SCENE= |right|CAPTION=Pectin methylesterase [[3uw0]] }} | ||
'''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.<br /> | '''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.<br /> | ||
* '''CheB ME''' is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors.<br /> | * '''CheB ME''' is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors<ref>PMID:7608964</ref>.<br /> | ||
* '''Pectin ME''' causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle.<br /> | * '''Pectin ME''' causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle<ref>PMID:11544130</ref>.<br /> | ||
* '''Aclacinomycin ME''' modifies the aklavinone skeleton in the biosynthesis of anthracyclins in ''Streptomyces'' species. <br /> | * '''Aclacinomycin ME''' modifies the aklavinone skeleton in the biosynthesis of anthracyclins in ''Streptomyces'' species<ref>PMID:11934504</ref>. <br /> | ||
* '''Protein phosphatase ME''' is a key regulator of protein phosphatase 2A.<br /> | * '''Protein phosphatase ME''' is a key regulator of protein phosphatase 2A<ref>PMID:24928782</ref>.<br /> | ||
* '''4-o-methyl-glucuronoyl ME''' has a significant role in biomass degradation.<br /> | * '''4-o-methyl-glucuronoyl ME''' has a significant role in biomass degradation<ref>PMID:16876163</ref>.<br /> | ||
==3D structures of methylesterase== | ==3D structures of methylesterase== | ||
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**[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br /> | **[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br /> | ||
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== References == | |||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||