Lactoperoxidase

Function Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion. Relevance The short-lived oxidized intermediates of the LPO reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. Structural highlights The peroxidation of thiocyanate catalyzed by LPO occurs at the heme cavity site.

spinqualitylabelsall models Human α-defensin 1 (PDB entry 2pm4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of lactoperoxidase3D structures of lactoperoxidase

Updated on 10-April-2016

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• Lactoperoxidase binary complex
  • 2pt3 - bPLO + phosphate - bovine
    
  • 2nqx – bPLO + I
    
  • 2r5l – gLPO + I – goat
    
  • 3nak – gLPO + formate
    
  • 4ig5, 4qyq – gLPO + antithyroid agent
    
• Lactoperoxidase ternary complex
  • 2gj1 – bLPO + carbonate + nitrate
    
  • 2ips, 3eri, 3gc1 – bLPO + SCN + I
    
  • 2qrb – bLPO + SCN + Cl
    
  • 3bxi – bLPO + SCN + nitrate
    
  • 4pnx - bPLO + bromomethane + I
    
  • 2pum – bPLO + catechol + I
    
  • 2gj1 – bLPO + carbonate + nitrate
    
  • 3krq – bLPO + amino-triazole + I
    
  • 2z5z – wbPLO + F + I – water buffalo
    
  • 2o86 – wbPLO + nitrate + I
    
  • 3erh - wbLPO + SCN + I
    
  • 2ojv – gPLO + CN + I
    
  • 3n8f - gLPO + SCN + nitrate
    
  • 3niu – gLPO + diethylene glycol + phosphate
    
  • 3rke - gPLO + inhibitor + I
    
  • 2ikc – sLPO + carbonate + formate – sheep
• Lactoperoxidase quaternary complex
  • 3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
    
  • 3gck - bPLO + benzylhydroxamic acid + SCN + I
    
  • 3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
    
  • 3gcl, 2qqt - bPLO + aspirin + SCN + I
    
  • 3i6n - bPLO + isoniazid + SCN + I
    
  • 4ksz - bPLO + cystein + SCN + I
    
  • 3nyh - bPLO + Br + Cl + SCN + I
    
  • 3ogw - bPLO + indomethacin + SCN + I
    
  • 3py4, 4gn6 - bPLO + paracetamol + SCN + I
    
  • 3q9k - bPLO + phenyliso-SCN + SCN + I
    
  • 3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
    
  • 3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
    
  • 3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
    
  • 3r5o - bPLO + methoxyphenol + SCN + I
    
  • 3tgy - bPLO + ascorbate + SCN + I
    
  • 3v6q - bPLO + CO + SCN + I
    
  • 2gjm - wbPLO + carbonate + SCN + I
    
  • 3faq – wbLPO + CN + SCN + I
    
  • 3fnl - wbPLO + salicylhydroxamic acid + SCN + I
    
  • 2e9e – gPLO + nitrate + carbonate + SCN + CN
    
  • 2efb – gPLO + phosphate + carbonate + SCN + CN
    
  • 3qf1 - gPLO + piperazine + SCN + I
    
  • 4ljj - gPLO + acrylonitrile + SCN + I
    
  • 4msf, 4oek - gPLO + phenol derivative+ SCN + I
    
  • 2eha – gPLO + formate + carbonate + SCN
    
  • 3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
    
  • 3sxv - gPLO + amitrole + SCN + I
    
  • 3r5q - sPLO +tetrahydrofuran + SCN + I
    
  • 4qjq - gPLO + octopamine + SCN + I
    
  • 4s0y - bLPO + butyl-triazole + SCN + I
    
  • 4y55 - wbLPO + rhodanide + SCN + I