Histone: Difference between revisions

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{{STRUCTURE_2hue|  PDB=2hue  | SIZE=400| SCENE= |right|CAPTION=Yeast H3 (green), H4 (pink) and anti-silencing protein (grey) complex with sulfate, glycerol and Zn+2 ion (grey), [[2hue]] }}
{{STRUCTURE_2hue|  PDB=2hue  | SIZE=400| SCENE= |right|CAPTION=Yeast H3 (green), H4 (pink) and anti-silencing protein (grey) complex with sulfate, glycerol and Zn+2 ion (grey), [[2hue]] }}


'''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones<ref>PMID:16209651</ref>.  The '''nucleosome''' is the repeated unit of the chromatin consisting of 8 histone molecules wrapped by ca. 200 base pairs of DNA<ref>PMID:4825889</ref>.<br />
'''Histones''' (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones<ref>PMID:16209651</ref>.  The '''nucleosome''' is the repeated unit of the chromatin consisting of a core which contains 8 histone molecules (two copies of H2A, H2B, H3 and H4) wrapped by ca. 140 base pairs of DNA<ref>PMID:4825889</ref>.  The '''chromatin''' is made of nucleosome cores separated by a linker region of upto 80 base pairs of DNA associated with histones H1 and H5.<br />
* For the hyperthermophilic histones see [[Archaeal Histones]].<br />
* For the hyperthermophilic histones see [[Archaeal Histones]].<br />
* For nucleosome structure see [[User:Eric Martz/Nucleosomes]], [[Nucleosome structure]] and [[Nucleosomes]].
* For nucleosome structure see [[User:Eric Martz/Nucleosomes]], [[Nucleosome structure]] and [[Nucleosomes]].

Revision as of 14:14, 22 March 2016

Template:STRUCTURE 2hue

Histones (H) are the major protein components of chromatin which help to pack the DNA in the nucleosomes. H2A, H2B, H3 and H4 are core histones while H1 and H5 are linker histones[1]. The nucleosome is the repeated unit of the chromatin consisting of a core which contains 8 histone molecules (two copies of H2A, H2B, H3 and H4) wrapped by ca. 140 base pairs of DNA[2]. The chromatin is made of nucleosome cores separated by a linker region of upto 80 base pairs of DNA associated with histones H1 and H5.

3D Structures of histone3D Structures of histone

Updated on 22-March-2016

ReferencesReferences

  1. ↑ Marino-Ramirez L, Kann MG, Shoemaker BA, Landsman D. Histone structure and nucleosome stability. Expert Rev Proteomics. 2005 Oct;2(5):719-29. PMID:16209651 doi:http://dx.doi.org/10.1586/14789450.2.5.719
  2. ↑ Kornberg RD. Chromatin structure: a repeating unit of histones and DNA. Science. 1974 May 24;184(4139):868-71. PMID:4825889

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