1env

ATOMIC STRUCTURE OF THE ECTODOMAIN FROM HIV-1 GP41ATOMIC STRUCTURE OF THE ECTODOMAIN FROM HIV-1 GP41

Structural highlights 1env is a 1 chain structure with sequence from Hiv-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: GP41 (HIV-1) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Fusion of viral and cellular membranes by the envelope glycoprotein gp120/gp41 effects entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 and gp41 which remain non-covalently associated. Binding to both CD4 and a co-receptor leads to the conformational changes in gp120/gp41 needed for membrane fusion. We used X-ray crystallography to determine the structure of the protease-resistant part of a gp41 ectodomain solubilized with a trimeric GCN4 coiled coil in place of the amino-terminal fusion peptide. The core of the molecule is found to be an extended, triple-stranded alpha-helical coiled coil with the amino terminus at its tip. A carboxy-terminal alpha-helix packs in the reverse direction against the outside of the coiled coil, placing the amino and carboxy termini near each other at one end of the long rod. These features, and the existence of a similar reversal of chain direction in the fusion pH-induced conformation of influenza virus HA2 and in the transmembrane subunit of Moloney murine leukaemia virus (Fig. 1a-d), suggest a common mechanism for initiating fusion. Atomic structure of the ectodomain from HIV-1 gp41.,Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC Nature. 1997 May 22;387(6631):426-30. PMID:9163431 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Gcn4 Gp41

spinqualitylabelsall models 1env, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image