2v02: Difference between revisions
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<StructureSection load='2v02' size='340' side='right' caption='[[2v02]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2v02' size='340' side='right' caption='[[2v02]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2v02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V02 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aji|1aji]], [[1cdl|1cdl]], [[1cll|1cll]], [[1ctr|1ctr]], [[1iwq|1iwq]], [[1j7o|1j7o]], [[1j7p|1j7p]], [[1k90|1k90]], [[1k93|1k93]], [[1l7z|1l7z]], [[1lvc|1lvc]], [[1nkf|1nkf]], [[1pk0|1pk0]], [[1s26|1s26]], [[1sk6|1sk6]], [[1sw8|1sw8]], [[1wrz|1wrz]], [[1xfu|1xfu]], [[1xfv|1xfv]], [[1xfw|1xfw]], [[1xfx|1xfx]], [[1xfy|1xfy]], [[1xfz|1xfz]], [[1y6w|1y6w]], [[1yr5|1yr5]], [[1yrt|1yrt]], [[1yru|1yru]], [[1zot|1zot]], [[2be6|2be6]], [[2f3y|2f3y]], [[2f3z|2f3z]], [[2v01|2v01]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aji|1aji]], [[1cdl|1cdl]], [[1cll|1cll]], [[1ctr|1ctr]], [[1iwq|1iwq]], [[1j7o|1j7o]], [[1j7p|1j7p]], [[1k90|1k90]], [[1k93|1k93]], [[1l7z|1l7z]], [[1lvc|1lvc]], [[1nkf|1nkf]], [[1pk0|1pk0]], [[1s26|1s26]], [[1sk6|1sk6]], [[1sw8|1sw8]], [[1wrz|1wrz]], [[1xfu|1xfu]], [[1xfv|1xfv]], [[1xfw|1xfw]], [[1xfx|1xfx]], [[1xfy|1xfy]], [[1xfz|1xfz]], [[1y6w|1y6w]], [[1yr5|1yr5]], [[1yrt|1yrt]], [[1yru|1yru]], [[1zot|1zot]], [[2be6|2be6]], [[2f3y|2f3y]], [[2f3z|2f3z]], [[2v01|2v01]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v02 RCSB], [http://www.ebi.ac.uk/pdbsum/2v02 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v02 OCA], [http://pdbe.org/2v02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v02 RCSB], [http://www.ebi.ac.uk/pdbsum/2v02 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v02 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2v02" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Kursula, P]] | [[Category: Kursula, P]] | ||
[[Category: Majava, V]] | [[Category: Majava, V]] | ||
Revision as of 19:08, 7 February 2016
RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BARECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedCalmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans. A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.,Kursula P, Majava V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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