Fibroblast growth factor

Function Fibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF1 is called acidic FGF. FGF2 is called basic FGF. FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound. Relevance FGF signaling is important in the pathogenesis of a variety of tumor types, angiogenesis and wound healing. Structural insights The heparin binds in the dimer interface.

spinqualitylabelsall models Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code 2uus) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of fibroblast growth factor3D structures of fibroblast growth factor

Updated on 22-January-2016

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• FGF1
  • 1fmm – FGF1 – Notophthalmus viridescens - NMR
    
  • 1afc – bFGF1 + HS – bovine
    
  • 1bar – bFGF1
    
  • 2j3p – rFGF1 - rat
    
  • 3hal – FGF1 - rabbit
    
  • 2afg, 1jqz, 1rg8 – hFGF1 - human
    
  • 1jt3, 1jt4, 1jt5, 1jt7, 1jtc, 1k5u, 1k5v, 1m16, 1jy0, 1nzk, 1p63, 1pzz, 1q03, 1q04, 1yto, 1z2v, 1z4s, 2aqz, 2hw9, 2hwa, 2hwm, 2hz9, 2ntd, 3b9u, 3ba4, 3ba5, 3ba7, 3bad, 3bag, 3bah, 3bao, 3baq, 3bau, 3bav, 3bb2, 2q9x, 3crg, 3crh, 3cri, 3cqa, 3fgm, 3fj8, 3fj9, 3fja, 3fjb, 3fjc, 3fjd, 3fje, 3fjf, 3fjh, 3fji, 3fjj, 3fjk, 3hom, 3o3q, 4q91, 4q9g, 4q9p, 4qal, 4qbc, 4qbv, 4qc4 – hFGF1 (mutant)
    
  • 1dzd, 2rq9 – hFGF1 - NMR
    
  • 1dzc – hFGF1 (mutant) - NMR
    
• FGF1 complex with small molecule
  • 1axm, 2axm – hFGF1 + HS
    
  • 3ud7, 3ud8, 3ud9, 3uda – hFGF1 + disaccharide
    
  • 2uus – rFGF1 + HS
    
  • 2erm – hFGF1 + HS - NMR
    
  • 1rml – hFGF1 + naphthalene trisulphonate - NMR
    
  • 1hkn – hFGF1 + naphthalene trisulphonate
    
  • 2k8r – hFGF1 + anti-angiogenic drug - NMR
    
  • 3k1x – hFGF1 + vasoprotectant drug
    
  • 3jut – hFGF1 + inhibitor
    
  • 2ki4, 2ki6 – hFGF1 + S100-A13
    
• FGF1 complex with FGF receptor
  • 1e0o – hFGF1 (mutant) + hFGFR2 (mutant) + HS
    
  • 3oj2, 3ojm, 1djs – hFGF1 + hFGFR2 (mutant)
    
  • 1evt – hFGF1 + hFGFR1
    
  • 3ojv – hFGF1 + hFGFR1 (mutant)
    
  • 1ry7 – hFGF1 + hFGFR3
    
  • 3cu1 – hFGF1 + hFGFR2
    
  • 4j23 – hFGF1 + hFGFR2 + inhibitor
    
• FGF2
  • 2fgf – hFGF2 precursor
    
  • 1fga, 4fgf, 1bas, 1bfg, 2bfh, 1bff – hFGF2
    
  • 1wvz, 2k43, 2k4a – hFGF2 - NMR
    
  • 1bla, 1bld – hFGF2 (mutant) - NMR
    
  • 1bfb, 1bfc – hFGF2 + heparin
    
  • 1cvs – hFGF2 (mutant) + hFGFR1 (mutant)
    
  • 1fq9 – hFGF2 (mutant) + hFGFR1 (mutant) + HS
    
  • 1ev2 - hFGF2 (mutant) + hFGFR2
    
  • 2m49 - hFGF2 (mutant) + S100-B
    
  • 4oee, 4oef, 4oeg - hFGF2 (mutant) + disaccharide
    
• FGF4
  • 1ijt – hFGF4 b-trefoil domain
    
• FGF7
  • 1qqk – rFGF7
    
  • 1qql – rFGF7/hFGF1
    
• FGF8
  • 2fdb – hFGF8b + hFGFR2
    
• FGF9
  • 1g82, 1ihk – hFGF9
    
• FGF10
  • 1nun – hFGF10 + hFGFR2
    
• FGF12
  • 1q1u – hFGF12 (mutant)
    
• FGF13
  • 3hbw – hFGF13
    
  • 4dck – hFGF13 + calmodulin + sodium channel subunit α
    
• FGF18
  • 4cjm – hFGF18
    
• FGF19
  • 1pwa, 2p23 – hFGF19
    
• FGF20
  • 3f1r – hFGF20
    
• FGF23
  • 2p39 – hFGF23