BAG protein: Difference between revisions

Revision as of 15:31, 13 January 2016

Function

The BAG family proteins (Bcl-2 associated athanogenes) perform diverse functions. BAG-1, BAG-2, BAG-4, BAG-5 or BAG family molecular chaperone regulator inhibit the chaperone function of HSC70 and have anti-apoptotic function. ^[1]

Structural highlights

BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.

Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (stick model) (PDB entry 3fzf)

Drag the structure with the mouse to rotate

3D structures of BAG family proteins3D structures of BAG family proteins

Updated on 13-January-2016

ReferencesReferences

↑ Kabbage M, Dickman MB. The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci. 2008 May;65(9):1390-402. doi: 10.1007/s00018-008-7535-2. PMID:18264803 doi:http://dx.doi.org/10.1007/s00018-008-7535-2

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Kabbage M, Dickman MB. The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci. 2008 May;65(9):1390-402. doi: 10.1007/s00018-008-7535-2. PMID:18264803 doi:http://dx.doi.org/10.1007/s00018-008-7535-2

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Revision as of 10:42, 30 November 2015 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 15:31, 13 January 2016 view source Alexander Berchansky (talk \| contribs) 29,637 edits No edit summary Newer edit →
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	<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (stick model) (PDB entry [[3fzf]])' scene=''>		<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (stick model) (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>

	== Function ==		== Function ==