Dethiobiotin synthetase: Difference between revisions

Revision as of 15:23, 29 December 2015

Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.^[1]

Structural highlights

The .^[2]

Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry 1a82)

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3D dethiobiotin synthetase3D dethiobiotin synthetase

Updated on 29-December-2015

ReferencesReferences

↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568

[2] Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910

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 == Structural highlights ==
-The <scene name='49/493028/Cv/3'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref>
+The <scene name='49/493028/Cv/4'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref>
 </StructureSection>
 ==3D dethiobiotin synthetase==