Cyclin: Difference between revisions

Revision as of 15:59, 21 December 2015

Function

Cyclin (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs, CYCA is active in the S phase, CYCD regulate the transition from G1 to S.^[1] See also Intrinsically Disordered Protein.

Structural highlights

All cyclins have an all-α helix fold and share an identical ca. 100 residue domain called 'cyclin box' which binds CDK. Two 5 α-helix cyclin boxes are shown.^[2]

3D Structures of Cyclin3D Structures of Cyclin

Updated on 21-December-2015

ReferencesReferences

↑ Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. PMID:12910258 doi:http://dx.doi.org/10.1038/sj.onc.1206558
↑ Noble ME, Endicott JA, Brown NR, Johnson LN. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci. 1997 Dec;22(12):482-7. PMID:9433129

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. PMID:12910258 doi:http://dx.doi.org/10.1038/sj.onc.1206558

[2] Noble ME, Endicott JA, Brown NR, Johnson LN. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci. 1997 Dec;22(12):482-7. PMID:9433129

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	<StructureSection load='3blh' size='350' side='right' caption='Cyclin T1 (green) complex with CDK9 (~~grey~~) and TRIS (PDB entry [[3blh]])' scene=''>		<StructureSection load='3blh' size='350' side='right' caption='Cyclin T1 (green) complex with CDK9 (cyan) and TRIS (PDB entry [[3blh]])' scene='44/442748/Cv/2'>
	== Function ==		== Function ==