Atlastin: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
*<scene name='59/590828/Cv/5'>GDP/AlF4 binding site</scene> | *<scene name='59/590828/Cv/5'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref>PMID:23334294</ref> | ||
</StructureSection> | </StructureSection> | ||
==3D structures of atlastin== | ==3D structures of atlastin== | ||
Revision as of 14:59, 10 December 2015
FunctionAtlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.[1] DiseaseDefects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Structural highlights |
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3D structures of atlastin3D structures of atlastin
Updated on 10-December-2015
3q5d, 3q5e, 3qnu, 3qof – hATN cytoplasmic domain + GDP – human
4idn – hATN cytoplasmic domain + GNP
4idp – hATN cytoplasmic domain (mutant) + GNP
4ido – hATN cytoplasmic domain + GDP + AlF4
4idq – hATN cytoplasmic domain (mutant) + GDP + AlF4
ReferencesReferences
- ↑ Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353
- ↑ Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353