Chromodomain-helicase-DNA-binding protein: Difference between revisions

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<StructureSection load='2b2u' size='350' side='right' caption='Tandem chromodomains of human CHD1 (grey, green, pink) complex with histone H3 tail peptide (yellow) containing trimethyllysine and dimethylarginine (PDB entry [[2b2u]])' scene=''>


<StructureSection load='2b2u' size='350' side='right' caption='Tandem chromodomains of human CHD1 (grey, green, pink) complex with histone H3 tail peptide (yellow) containing trimethyllysine and dimethylarginine (PDB entry [[2b2u]])' scene=''>
__TOC__
== Function ==
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Revision as of 12:00, 8 December 2015


Chromodomain-helicase-DNA-binding proteins (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower. CHDs contain several domains such as chromodomain which is found in proteins involved in chromatin remodeling, PHD zinc finger which has Cys4-His-Cys3 motif and BRK domain which is associated with chromodomains.[1]

  • CHD1 - ATP-dependent chromatin-modeling factor. Functions as substrate recognition component of the transcription regulatory acetylation complex SAGA.
  • CHD4 - Chromatin-modeling factor. Functions as component of the transcription regulatory deacetylation complex NuRD.
  • CHD6 - Probable transcription regulator.
  • CHD7 - ATP-dependent chromatin-modeling factor. May be involved in the 45S precursor ribosomal RNA production.
  • CHD8 - acts as transcription repressor by modeling chromatin structure and recruiting histone H1 to target genes.

Tandem chromodomains of human CHD1 (grey, green, pink) complex with histone H3 tail peptide (yellow) containing trimethyllysine and dimethylarginine (PDB entry 2b2u)

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3D structures of CHD3D structures of CHD

Updated on 08-December-2015

2b2t – hCHD1 (mutant) + histone H3 tail – human
2b2u, 2b2v, 2b2w - hCHD1 + histone H3 tail
2b2y - hCHD1 chromodomains
4b4c – hCHD1 DNA-binding domain
4nw2 - hCHD1 chromodomains + nonstructural protein
2l5u – hCHD4 PHD finger 1 – NMR
2l75 - hCHD4 PHD finger 2 + histone H3 peptide – NMR
2ee1 – hCHD4 chromodomain – NMR
1mm2, 1mm3 - hCHD4 PHD finger 2 – NMR
2epb – hCHD6 chromodomain 2 – NMR
2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
2dl6, 2cka – hCHD8 BRK domain - NMR

ReferencesReferences

  1. ↑ Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS. Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11472-7. PMID:9326634

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Michal Harel, Alexander Berchansky
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