Rho guanine nucleotide exchange factor

Rho guanine nucleotide exchange factor (Rho) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of Rho to GDP-GTPase catalyzes the dissociation of GDP from the protein. Rho domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.

spinqualitylabelsall models Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey and green) complex with transforming protein RhoA (magenta and cyan), GSP and Mg+2 ion (PDB code 3kz1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Rho guanine nucleotide exchange factor3D Structures of Rho guanine nucleotide exchange factor

Updated on 16-July-2015

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• Rho guanine nucleotide exchange factor 1 (P115-RhoGEF)
  • 1iap – hRho N terminal - human
    
  • 3odo, 3odw, 3odx – hRho DH/PH domain
    
  • 3p6a – hRho DH/PH domain (mutant)
    
  • 1shz, 3ab3 – hRho N terminal + guanine nucleotide-binding protein
    
• Rho guanine nucleotide exchange factor 4 (Asef)
  • 2dx1, 2pz1 – hRho
    
  • 3nmx, 3nmz – hRho + APC variant protein
    
• Rho guanine nucleotide exchange factor 6
  • 1ujy – hRho SH3 domain - NMR
    
  • 1wyr – hRho CH domain - NMR
    
• Rho guanine nucleotide exchange factor 7 (β-PIX)
  • 1by1 – hRho DH domain - NMR
    
  • 2l3g – hRho CH domain - NMR
    
  • 2esw – Rho SH3 domain – mouse
    
  • 2g6f – rRho SH3 domain – rat
    
  • 2w6b – rRho coiled-coil domain
    
• Rho guanine nucleotide exchange factor 7 complex with peptide
  • 2ak5 – hRho SH3 domain + CBL-b peptide
    
  • 2df6 – hRho SH3 domain + PAK-1 peptide
    
  • 1zsg – hRho residues 179-243 + PAK-1 peptide – NMR
    
  • 2p4r – rRho SH3 domain + E3 ubiquitin protein ligase peptide
    
  • 3l4f – rRho coiled-coil domain + SHANK1 PDZ domain
    
• Rho guanine nucleotide exchange factor 8 (PRONE8)
  • 2ntx – AtRho PRONE domain – Arabidopasis thaliana
    
  • 2wbl – AtRho PRONE domain + GTPase ROP7
    
  • 2nty – AtRho PRONE domain + GTPase ROP4 + GDP
    
  • 3eo2 – hRho residues 161-373
    
  • 4xh9 – hRho DH/PH domain + transforming protein RhoA
    
• Rho guanine nucleotide exchange factor 9 (collybistin)
  • 2ysq – hRho SH3 domain - NMR
    
  • 4mt6, 4mt7 – rRho (mutant)
    
  • 2dfk – rRho + CDC42
    
• Rho guanine nucleotide exchange factor 11
  • 2dls – hRho PDZ domain - NMR
    
  • 3kz1, 3t06 – hRho DH/PH domain + transforming protein RhoA
    
  • 1xcg – hRho DH/PH domain + transforming protein RhoA - NMR
    
  • 3cx6 – rRho RGS domain + guanine nucleotide-binding protein
    
• Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
  • 1txd – hRho DH/PH domain
    
  • 2omj – hRho PDZ domain
    
  • 1x86 – hRho DH/PH domain (mutant) + transforming protein RhoA
    
  • 2os6 – hRho PDZ domain + plexin peptide – NMR
    
• Rho guanine nucleotide exchange factor 16
  • 1x6b – hRho SH3 domain - NMR