Undecaprenyl pyrophosphate synthase

Function Undecaprenyl pyrophosphate synthase (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Bisphosphonate drugs are UPP inhibitors.

spinqualitylabelsall models Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of undecaprenyl pyrophosphate synthase3D structures of undecaprenyl pyrophosphate synthase

Updated on 24-June-2015

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• Undecaprenyl pyrophosphate synthase
  • 1f75 – UPP (mutant) – Micrococcus luteus
    
  • 3qas – EcUPP – Escherichia coli
    
  • 1jp3 – EcUPP (mutant)
    
  • 2d2r – HpUPP (mutant) – Helicobacter pylori
    
  • 2vg4 – MtUPP – Mycobacterium tuberculosis
    
• Undecaprenyl pyrophosphate synthase complexes
  • 1ueh – EcUPP + Mg + SO4 + triton
    
  • 1v7u – EcUPP + FPP
    
  • 1x06 – EcUPP + Mg + FPP analog + IPP
    
  • 1x08 – EcUPP (mutant) + Mg + FPP analog + IPP
    
  • 1x07 – EcUPP + Mg + PO4 + IPP
    
  • 1x09 – EcUPP (mutant) + Mg + IPP
    
  • 2e98, 2e99, 2e9a, 2e9c, 2e9d, 3th8, 3sgt, 3sgv, 3sgx, 3sh0, 4h2j, 4h2m, 4h2o, 4h38, 4h3c, 4h3a, 4h8e – EcUPP + bisphosphonate
    
  • 2dtn – HpUPP + pyrophosphate
    
  • 3ugs - UPP + FPP analog – Campylobacter jejuni
    
  • 2vg2 – MtUPP + Pi + PPi + methyl butenyl diphosphate
    
  • 2vg3 – MtUPP + Pi + Mg + geranyl diphosphate