Leukocyte immunoglobulin-like receptor

Leukocyte immunoglobulin-like receptors (LIR) or CD85 have extracellular immunoglobulin domains. LIR modulates a variety of immune cells. LIR interacts with class I MHC molecules.

spinqualitylabelsall models Structure of human leukocyte immunoglobulin-like receptor ligand-binding domain (yellow) complex with class I MHC (grey), β-2 microglobulin (green) and POL polyprotein peptide (pink) (PDB entry 1p7q) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of leukocyte immunoglobulin-like receptor3D structures of leukocyte immunoglobulin-like receptor

Updated on 04-May-2015

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• LIR-1
  • 1g0x, 1ufu – hLIR ligand-binding domain – human
    
  • 1ugn, 1vdg – hLIR ligand-binding domain (mutant)
    
  • 3kgr, 3rp1 – hLIR ectodomain
    
  • 4esk, 4ety – LIR ectodomain - mouse
    
• LIR-1 complexes
  • 1p7q – hLIR ligand-binding domain + class I MHC + β-2 microglobulin + POL polyprotein peptide
    
  • 3d2u – hLIR ligand-binding domain + herpesvirus UL18 + β-2 microglobulin + actin peptide